[HTML][HTML] Schizophrenia genomics: convergence on synaptic development, adult synaptic plasticity, or both?
J Hall, NJ Bray - Biological Psychiatry, 2022 - Elsevier
Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci
conferring risk to the disorder. This progress offers an important route toward defining the …
conferring risk to the disorder. This progress offers an important route toward defining the …
Targeting synaptic plasticity in schizophrenia: insights from genomic studies
Patients with schizophrenia experience cognitive dysfunction and negative symptoms that
do not respond to current drug treatments. Historical evidence is consistent with the …
do not respond to current drug treatments. Historical evidence is consistent with the …
Genetic risk for schizophrenia: convergence on synaptic pathways involved in plasticity
J Hall, S Trent, KL Thomas, MC O'Donovan… - Biological psychiatry, 2015 - Elsevier
Recent large-scale genomic studies have revealed two broad classes of risk alleles for
schizophrenia: a polygenic component of risk mediated through multiple common risk …
schizophrenia: a polygenic component of risk mediated through multiple common risk …
Schizophrenia genomics: genetic complexity and functional insights
Determining the causes of schizophrenia has been a notoriously intractable problem,
resistant to a multitude of investigative approaches over centuries. In recent decades …
resistant to a multitude of investigative approaches over centuries. In recent decades …
Genetic architecture of schizophrenia: a review of major advancements
SE Legge, ML Santoro, S Periyasamy… - Psychological …, 2021 - cambridge.org
Schizophrenia is a severe psychiatric disorder with high heritability. Consortia efforts and
technological advancements have led to a substantial increase in knowledge of the genetic …
technological advancements have led to a substantial increase in knowledge of the genetic …
Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia
Schizophrenia Working Group of the Psychiatric … - MedRxiv, 2020 - medrxiv.org
Schizophrenia is a psychiatric disorder whose pathophysiology is largely unknown. It has a
heritability of 60-80%, much of which is attributable to common risk alleles, suggesting …
heritability of 60-80%, much of which is attributable to common risk alleles, suggesting …
Genomic insights into schizophrenia
MJ Owen - Royal Society Open Science, 2023 - royalsocietypublishing.org
Schizophrenia is a common, complex, heterogeneous psychiatric syndrome which can have
profound impacts on affected individuals and imposes significant burdens on society …
profound impacts on affected individuals and imposes significant burdens on society …
Genetic insights into the neurodevelopmental origins of schizophrenia
R Birnbaum, DR Weinberger - Nature Reviews Neuroscience, 2017 - nature.com
Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of
neurobiological investigation. Although the underlying causal mechanisms remain …
neurobiological investigation. Although the underlying causal mechanisms remain …
[HTML][HTML] The synaptic hypothesis of schizophrenia version III: a master mechanism
OD Howes, EC Onwordi - Molecular Psychiatry, 2023 - nature.com
The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …
approaches mean there has been a step-change in the evidence available, and some tenets …
Synaptic dysfunction in schizophrenia
DM Yin, YJ Chen, A Sathyamurthy, WC Xiong… - Synaptic Plasticity …, 2012 - Springer
Schizophrenia alters basic brain processes of perception, emotion, and judgment to cause
hallucinations, delusions, thought disorder, and cognitive deficits. Unlike neurodegeneration …
hallucinations, delusions, thought disorder, and cognitive deficits. Unlike neurodegeneration …