Recent studies have revealed that T lymphocytes play a role in neuropathic pain following
nerve injury in rats through releasing several cytokines. Sirolimus is an immunosuppressive …

Sirolimus is an immunosupressive drug that specifically inhibit the activation of T-
lymphocytes. This study was undertaken to investigate whether treatment with sirolimus …

Proinflammatory cytokines are mediators of inflammatory and neuropathic pain. Here, we
investigated pain-related behavior in rats after intraneural injection of different doses of rat …

The expression of interleukin-1β and tumor necrosis factor has previously been shown to be
up-regulated in the spinal cord of several rat mononeuropathy models. This present study …

Background Evidence for a role of immune system in hyperalgesic pain states is increasing.
Recent work in neuroimmunology suggests that the immune system does more than simply …

Inflammatory mediators produced in the injured nerve have been proposed as contributing
factors in the development of neuropathic pain. In this regard an important role is assigned …

Antidepressants have been widely used to treat neuropathic pain for many years. However,
the mechanisms of their analgesic actions are little known and remain controvertible. Recent …

Nerve injury and the consequent release of interleukins (ILs) are processes implicated in
pain transmission. To study the potential role of IL-1 in the pathogenesis of allodynia and …

Background: Spinal nerve-ligated neuropathy and chemotherapy-induced neuropathy
produce a persistent tactile allodynia in mice. Tianeptine is an antidepressant that exhibits …

Background: Evidence indicates that neuropathic pain pathogenesis is not confined to
changes in the activity of neuronal systems but involves interactions between neurons …