Mouse bone marrow micronucleus assay: relationships with in vitro mutagenicity and rodent carcinogenicity
R Benigni - Journal of Toxicology and Environmental Health, Part A …, 1995 - Taylor & Francis
In this article, the relationship was studied between the in vivo mutagenicity assay of mouse
bone marrow micronucleus (MIC), and four in vitro assays: Salmonella typhimurium …
bone marrow micronucleus (MIC), and four in vitro assays: Salmonella typhimurium …
Evaluation of a three‐exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals
MD Shelby, GL Erexson, GJ Hook… - Environmental and …, 1993 - Wiley Online Library
Forty-nine chemicals were tested in a mouse bone marrow micronucleus test that employed
three daily exposures by intraperitoneal injection. Bone marrow samples were obtained 24 …
three daily exposures by intraperitoneal injection. Bone marrow samples were obtained 24 …
The rodent bone marrow micronucleus assay: contrast between its sensitivity to human carcinogens and its insensitivity to NTP rodent carcinogens
J Ashby, H Tinwell - … Research/Fundamental and Molecular Mechanisms of …, 1996 - Elsevier
The rodent bone marrow micronucleus (MN) assay occupies a critical position in the
accompanying schemes to detect potential human carcinogens and germ cell mutagens …
accompanying schemes to detect potential human carcinogens and germ cell mutagens …
Evaluation of the rodent micronucleus assay by a 28‐day treatment protocol: Summary of the 13th Collaborative Study by the Collaborative Study Group for the …
S Hamada, S Sutou, T Morita, A Wakata… - Environmental and …, 2001 - Wiley Online Library
To examine whether micronucleus tests can be incorporated into general toxicology assays,
we performed micronucleus tests applying the treatment protocols typically used in such …
we performed micronucleus tests applying the treatment protocols typically used in such …
The in vivo rat micronucleus test: integration with a 14-day study
ML Garriott, JD Brunny, DEF Kindig, JW Parton… - Mutation Research …, 1995 - Elsevier
A 14-day subchronic toxicity study is routinely conducted in Fischer 344 rats Lilly Research
Laboratories. This study is done to gather preliminary toxicological information about …
Laboratories. This study is done to gather preliminary toxicological information about …
Comparative activity of human carcinogens and NTP rodent carcinogens in the mouse bone marrow micronucleus assay: an integrative approach to genetic toxicity …
H Tinwell, J Ashby - Environmental Health Perspectives, 1994 - ehp.niehs.nih.gov
The mouse bone marrow micronucleus (MN) assay holds a key position in all schemes for
detecting potential human carcinogens and mutagens. It was therefore of concern when …
detecting potential human carcinogens and mutagens. It was therefore of concern when …
The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the US Environmental Protection Agency Gene-Tox Program
KH Mavournin, DH Blakey, MC Cimino… - … Research/Reviews in …, 1990 - Elsevier
The protocol recommended for the micronucleus assay in mammalian bone marrow has
been revised and simplified. The number of sample times has been reduced to one or two …
been revised and simplified. The number of sample times has been reduced to one or two …
Evaluation of the micronucleus test in vitro using Chinese hamster cells: results of four chemicals weakly positive in the in vivo micronucleus test
BM Miller, E Pujadas, E Gocke - Environmental and molecular …, 1995 - Wiley Online Library
A rapid and simple procedure for the micronucleus test (MNT) in vitro using Chinese
hamster ovary (CHO) cells was established in our laboratory. The assay is intended to …
hamster ovary (CHO) cells was established in our laboratory. The assay is intended to …
In vivo micronucleus assay in mouse bone marrow and peripheral blood
S Kasamoto, S Masumori, M Hayashi - Genotoxicity Assessment: Methods …, 2013 - Springer
The rodent micronucleus assay has been most widely and frequently used as a
representative in vivo assay system to assess mutagenicity of chemicals, regardless of …
representative in vivo assay system to assess mutagenicity of chemicals, regardless of …
Historical vehicle and positive control micronucleus data in mice and rats
G Krishna, G Urda, J Paulissen - Mutation Research/Fundamental and …, 2000 - Elsevier
The rodent bone marrow micronucleus (MN) assay has been widely used as part of an in
vivo genotoxicity test battery in product safety evaluation. In this assay, the historical vehicle …
vivo genotoxicity test battery in product safety evaluation. In this assay, the historical vehicle …