Genome sequencing of cancers often reveals mosaics of different subclones present in the
same tumour,–. Although these are believed to arise according to the principles of somatic …

The state and behaviour of a cell can be influenced by both genetic and environmental
factors. In particular, tumour progression is determined by underlying genetic aberrations …

Human cancers, including breast cancers, comprise clones differing in mutation content.
Clones evolve dynamically in space and time following principles of Darwinian evolution …

Genomic analysis provides insights into the role of copy number variation in disease, but
most methods are not designed to resolve mixed populations of cells. In tumours, where …

The sequencing of cancer genomes may enable tailoring of therapeutics to the underlying
biological abnormalities driving a particular patient's tumor. However, sequencing-based …

Sequencing studies of breast tumour cohorts have identified many prevalent mutations, but
provide limited insight into the genomic diversity within tumours. Here we developed a …

Subclonal architectures are prevalent across cancer types. However, the temporal
evolutionary dynamics that produce tumor subclones remain unknown. Here we measure …

The genetic evolutionary features of solid tumour growth are becoming increasingly well
described, but the spatial and physical nature of subclonal growth remains unclear. Here …

A substantial proportion of tumors consist of genotypically distinct subpopulations of cancer
cells. This intratumor genetic heterogeneity poses a substantial challenge for the …

Defining the transition from benign to malignant tissue is fundamental to improving early
diagnosis of cancer. Here we use a systematic approach to study spatial genome integrity in …