Anti-tumor effects in mice induced by survivin-targeted siRNA delivered through polysaccharide nanoparticles
Recently, survivin has been attracting great attention because it plays an important role in
inhibiting the apoptosis process of tumor cells. Down-regulating the expression of survivin …
inhibiting the apoptosis process of tumor cells. Down-regulating the expression of survivin …
Chitosan-based nanoparticles for survivin targeted siRNA delivery in breast tumor therapy and preventing its metastasis
P Sun, W Huang, M Jin, Q Wang, B Fan… - International journal …, 2016 - Taylor & Francis
Nanoparticle-mediated small interfering RNA (siRNA) delivery is a promising therapeutic
strategy in various cancers. However, it is difficult to deliver degradative siRNA to tumor …
strategy in various cancers. However, it is difficult to deliver degradative siRNA to tumor …
Enhancing anti-melanoma outcomes in mice using novel chitooligosaccharide nanoparticles loaded with therapeutic survivin-targeted siRNA
X Liu, L Chen, Y Zhang, X Xin, L Qi, M Jin… - European Journal of …, 2021 - Elsevier
Melanoma anti-tumor therapy remains a challenge. SiRNA-based therapies provide a
powerful means, but limitations remain in its pharmaceutical applications owing to the lack of …
powerful means, but limitations remain in its pharmaceutical applications owing to the lack of …
Synthesis and characterization of Fe3O4-PEG-LAC-chitosan-PEI nanoparticle as a survivin siRNA delivery system
S Arami, MR Rashidi, M Mahdavi… - Human & …, 2017 - journals.sagepub.com
The limited effectiveness of the conventional methods for cancer treatment makes the
researchers to find novel safe and effective therapeutic strategies. One of these strategies is …
researchers to find novel safe and effective therapeutic strategies. One of these strategies is …
Novel polyacrylate-based cationic nanoparticles for survivin siRNA delivery combined with mitoxantrone for treatment of breast cancer
As a gene delivery method in breast cancer therapy, knocking down the undesired genes in
the cancerous cells would be promising. Inhibitors of Apoptosis Protein (IAP) family genes …
the cancerous cells would be promising. Inhibitors of Apoptosis Protein (IAP) family genes …
[HTML][HTML] Apoptosis of A549 cells by small interfering RNA targeting survivin delivery using poly-β-amino ester/guanidinylated O-carboxymethyl chitosan nanoparticles
Y Tang, Y Liu, Y Xie, J Chen, Y Dou - Asian Journal of Pharmaceutical …, 2020 - Elsevier
Gene-based therapeutics has emerged as a promising approach for human cancer therapy.
Among a variety of non-viral vectors, polymer vectors are particularly attractive due to their …
Among a variety of non-viral vectors, polymer vectors are particularly attractive due to their …
Magnetic cationic amylose nanoparticles used to deliver survivin-small interfering RNA for gene therapy of hepatocellular carcinoma in vitro
Z Wu, XL Xu, JZ Zhang, XH Mao, MW Xie, ZL Cheng… - Nanomaterials, 2017 - mdpi.com
Amylose is a promising nanocarrier for gene delivery in terms of its good biocompatibility
and high transfection efficiency. Small interfering RNA against survivin (survivin-siRNA) can …
and high transfection efficiency. Small interfering RNA against survivin (survivin-siRNA) can …
[HTML][HTML] Evaluation of antitumor activity of survivin short interfering RNA delivered by lipid nanoparticles in colon cancer in vitro and in vivo
T Wang, Z Liu, Z Zhang, S Tang, M Yue… - Oncology …, 2017 - spandidos-publications.com
Survivin has been overexpressed in numerous types of cancer and is associated with a poor
clinical outcome. A number of various approaches have been used to counteract survivin in …
clinical outcome. A number of various approaches have been used to counteract survivin in …
Apoptosis induction activity and molecular docking studies of survivin siRNA carried by Fe3O4-PEG-LAC-chitosan-PEI nanoparticles in MCF-7 human breast cancer …
S Arami, M Mahdavi, MR Rashidi, R Yekta… - … of pharmaceutical and …, 2017 - Elsevier
Delivery of small interfering RNAs (siRNAs) into cells still remains a challenge in gene
delivery studies. Here, we investigated the ability of synthesized Fe 3 O 4-PEG-LAC …
delivery studies. Here, we investigated the ability of synthesized Fe 3 O 4-PEG-LAC …
GABAB receptor ligand-directed trimethyl chitosan/tripolyphosphate nanoparticles and their pMDI formulation for survivin siRNA pulmonary delivery
S Ni, Y Liu, Y Tang, J Chen, S Li, J Pu, L Han - Carbohydrate polymers, 2018 - Elsevier
The effect of gene silencing by survivin siRNA (siSurvivin) on the proliferation and apoptosis
of lung tumor has been attracted more interest. GABA B receptor ligand-directed …
of lung tumor has been attracted more interest. GABA B receptor ligand-directed …