Combination therapy of breast cancer by codelivery of doxorubicin and survivin siRNA using polyethylenimine modified silk fibroin nanoparticles
Here, polyethylenimine (PEI) modified silk fibroin nanoparticles (SFNPs) were prepared for
codelivery of doxorubicin (DOX) and survivin siRNA. The prepared NPs were characterized …
codelivery of doxorubicin (DOX) and survivin siRNA. The prepared NPs were characterized …
Reduction sensitive nanocarriers mPEG-g-γ-PGA/SSBPEI@ siRNA for effective targeted delivery of survivin siRNA against NSCLC
L Chen, S Wang, Q Liu, Z Zhang, S Lin, Q Zheng… - Colloids and Surfaces B …, 2020 - Elsevier
Poly γ-glutamic acid (γ-PGA) is attractive due to its desirable biological properties such as
nontoxicity, excellent biocompatibility, and minimal immunogenicity. Additionally, γ-PGA …
nontoxicity, excellent biocompatibility, and minimal immunogenicity. Additionally, γ-PGA …
Chitosan-based hybrid nanocomplex for siRNA delivery and its application for cancer therapy
MH Ki, JE Kim, YN Lee, SM Noh, SW An, HJ Cho… - Pharmaceutical …, 2014 - Springer
Purpose Chitosan, a natural and biocompatible cationic polymer, is an attractive carrier for
small interfering RNA (siRNA) delivery. The purpose of this study was to develop a chitosan …
small interfering RNA (siRNA) delivery. The purpose of this study was to develop a chitosan …
Development of a carrier system containing hyaluronic acid and protamine for siRNA delivery in the treatment of melanoma
J Yang, R Zhao, Q Feng, X Zhuo, R Wang - Investigational New Drugs, 2021 - Springer
The use of small interfering RNA (siRNA) in melanoma treatment remains limited owing to its
biological properties. Herein, we developed a carrier system containing hyaluronic acid and …
biological properties. Herein, we developed a carrier system containing hyaluronic acid and …
Smart polymeric nanoparticles with pH-responsive and PEG-detachable properties for co-delivering paclitaxel and survivin siRNA to enhance antitumor outcomes
M Jin, G Jin, L Kang, L Chen, Z Gao… - International journal of …, 2018 - Taylor & Francis
Background The co-delivery of chemotherapeutic agents and small interfering RNA (siRNA)
within one cargo can enhance the anticancer outcomes through its synergistic therapeutic …
within one cargo can enhance the anticancer outcomes through its synergistic therapeutic …
Oral delivery of shRNA and siRNA via multifunctional polymeric nanoparticles for synergistic cancer therapy
L Han, C Tang, C Yin - Biomaterials, 2014 - Elsevier
Galactose modified trimethyl chitosan-cysteine (GTC) conjugates with various galactose
grafting densities were developed for oral delivery of Survivin shRNA-expression pDNA …
grafting densities were developed for oral delivery of Survivin shRNA-expression pDNA …
Glioma Growth Inhibition In Vitro and In Vivo by Single Chain Variable Fragments of the Transferrin Receptor Conjugated to Survivin Small Interfering RNA
F Wang, HR Bai, J Wang, YZ Bai… - Journal of International …, 2011 - journals.sagepub.com
Inhibition of survivin by small interfering RNA (siRNA) can delay glioma growth. To enhance
the effect of survivin-siRNA on intercranial glioma, a conjugate of siRNA-survivin and single …
the effect of survivin-siRNA on intercranial glioma, a conjugate of siRNA-survivin and single …
Combination of Nanovectorized siRNA Directed against Survivin with Doxorubicin for efficient anti-cancer activity in HER2+ breast Cancer cells
S Eljack, E Allard-Vannier, Y Misericordia… - Pharmaceutics, 2022 - mdpi.com
According to Globocan 2020, breast cancer is considered one of the most common cancers
affecting women and is one of the leading causes of death in over 100 countries. The …
affecting women and is one of the leading causes of death in over 100 countries. The …
Targeted Delivery of siRNA‐Generating DNA Nanocassettes Using Multifunctional Nanoparticles
YS Cho, GY Lee, HK Sajja, W Qian, Z Cao, W He… - Small, 2013 - Wiley Online Library
Molecular therapy using a small interfering RNA (siRNA) has shown promise in the
development of novel therapeutics. Various formulations have been used for in vivo delivery …
development of novel therapeutics. Various formulations have been used for in vivo delivery …
Therapeutic potential of functionalized siRNA nanoparticles on regression of liver cancer in experimental mice
AA Khan, AM Alanazi, M Jabeen, A Chauhan… - Scientific reports, 2019 - nature.com
Short interfering RNA (siRNA) possesses special ability of silencing specific gene. To
increase siRNA stability, transportation and its uptake by tumor cells, effective delivery to the …
increase siRNA stability, transportation and its uptake by tumor cells, effective delivery to the …