Smart polymeric nanoparticles with pH-responsive and PEG-detachable properties (II): co-delivery of paclitaxel and VEGF siRNA for synergistic breast cancer therapy …
M Jin, Y Hou, X Quan, L Chen, Z Gao… - International Journal of …, 2021 - Taylor & Francis
Background The dual-loaded nano-delivery system can realize chemotherapeutic drug and
small interfering RNA (siRNA) co-loading as well as enhance the therapeutic effect of drugs …
small interfering RNA (siRNA) co-loading as well as enhance the therapeutic effect of drugs …
Enhancement of cisplatin sensitivity in lung cancer xenografts by liposome-mediated delivery of the plasmid expressing small hairpin RNA targeting Survivin
H Tian, S Liu, J Zhang, S Zhang… - Journal of …, 2012 - ingentaconnect.com
Survivin, a member of the inhibitor of apoptosis protein (IAP) family, is abundantly expressed
in a variety of cancer cells, including lung cancer cells, resulting in low sensitivity of these …
in a variety of cancer cells, including lung cancer cells, resulting in low sensitivity of these …
Knockdown of survivin gene by vector-based short hairpin RNA technique induces apoptosis and growth inhibition in Burkitt's lymphoma Raji cell line.
Survivin is the smallest member of mammalian IAP (inhibitor of apoptosis) family. It is
ubiquitous during embryonic development but is not expressed in normal post-natal tissues …
ubiquitous during embryonic development but is not expressed in normal post-natal tissues …
Oncolytic adenovirus mediated Survivin knockdown by RNA interference suppresses human colorectal carcinoma growth in vitro and in vivo
W Shen, CY Wang, XH Wang, ZX Fu - Journal of Experimental & Clinical …, 2009 - Springer
Background Colorectal cancer is a one of the most common alimentary malignancies.
Survivin has been proved by many studies to be an ideal target for cancer gene therapy …
Survivin has been proved by many studies to be an ideal target for cancer gene therapy …
Highly stable polyglutamate derivatives/siRNA polyplex efficiently down-relegate survivin expression and augment the efficacy of cisplatin
Z Wang, H Zou, Z Wang, J Wu, Z Xia, M Feng - International journal of …, 2016 - Elsevier
RNA interfere (RNAi)-based technology holds great promise in cancer treatment. The use of
small interfering RNA (siRNA), however, is hampered by its low delivery efficiency in vivo …
small interfering RNA (siRNA), however, is hampered by its low delivery efficiency in vivo …
Silencing of survivin and cyclin B1 through siRNA-loaded arginine modified calcium phosphate nanoparticles for non-small-cell lung cancer therapy
With the development of nanotechnology, various drug delivery systems including inorganic
nanoparticles, liposomes, polymers, etc. have been developed over the past decade. Some …
nanoparticles, liposomes, polymers, etc. have been developed over the past decade. Some …
An RGD-modified MRI-visible polymeric vector for targeted siRNA delivery to hepatocellular carcinoma in nude mice
C Wu, F Gong, P Pang, M Shen, K Zhu, D Cheng, Z Liu… - PloS one, 2013 - journals.plos.org
RNA interference (RNAi) has significant therapeutic promise for the genetic treatment of
hepatocellular carcinoma (HCC). Targeted vectors are able to deliver small interfering RNA …
hepatocellular carcinoma (HCC). Targeted vectors are able to deliver small interfering RNA …
[HTML][HTML] Downregulation of survivin by RNAi inhibits growth of human gastric carcinoma cells
GY Miao, QM Lu, XL Zhang - World Journal of Gastroenterology …, 2007 - ncbi.nlm.nih.gov
AIM: To investigate the inhibitory effect of a specific small survivin interfering RNA (siRNA)
on cell proliferation and the expression of survivin in human gastric carcinoma cell line SGC …
on cell proliferation and the expression of survivin in human gastric carcinoma cell line SGC …
Survivin small interfering RNA transfected with a microbubble and ultrasound exposure inducing apoptosis in ovarian carcinoma cells
J jun Wang, Y Zheng, F Yang, P Zhao… - International Journal of …, 2010 - ijgc.bmj.com
Introduction: Small interfering RNA (siRNA) has been used to knock down the expression of
specific genes. However, its delivery remains a challenge. Recently, ultrasound combined …
specific genes. However, its delivery remains a challenge. Recently, ultrasound combined …
[HTML][HTML] Silencing of survivin expression leads to reduced proliferation and cell cycle arrest in cancer cells
Survivin is an anti-apoptotic gene that is overexpressed in most human tumors. RNA
interference using short interfering RNA (siRNA) can be used to specifically inhibit survivin …
interference using short interfering RNA (siRNA) can be used to specifically inhibit survivin …