It is now established that airway smooth muscle (ASM) has roles in determining airway
structure and function, well beyond that as the major contractile element. Indeed, changes in …

Airway structure and function are key aspects of normal lung development, growth, and
aging, as well as of lung responses to the environment and the pathophysiology of important …

Airway smooth muscle (ASM) plays a pivotal role in modulating bronchomotor tone but also
orchestrates and perpetuates airway inflammation and remodeling. Despite substantial …

Airway smooth muscle (ASM), an important tissue involved in the regulation of bronchomotor
tone, exists in the trachea and in the bronchial tree up to the terminal bronchioles. The …

Chronic asthma is an inflammatory airways disease characterized by pathological changes
in the airway smooth muscle (ASM) bundle that contribute to airway obstruction and …

The airway smooth muscle (ASM) cell plays a central role in the pathogenesis of asthma and
constitutes an important target for treatment. These cells control muscle tone and thus …

Asthma is an obstructive airway disease, with a heterogeneous and multifactorial
pathogenesis. Although generally considered to be a disease principally driven by chronic …

Recent evidence points to progressive structural change in the airway wall, driven by
chronic local inflammation, as a fundamental component for development of irreversible …

Ultimately, asthma is a disease characterized by constriction of airway smooth muscle
(ASM). The earliest approach to the treatment of asthma comprised the use of xanthines and …

Airway smooth muscle (ASM) plays an integral part in the pathophysiology of asthma. It is
responsible for acute bronchoconstriction, which is potentiated by constrictor …