Normothermic liver preservation: a new paradigm?
R Ravikumar, H Leuvenink… - Transplant international, 2015 - Wiley Online Library
Despite increasing donor numbers, waiting lists and pre‐transplant mortality continue to
grow in many countries. The number of donor organs suitable for liver transplantation is …
grow in many countries. The number of donor organs suitable for liver transplantation is …
Technique of subnormothermic ex vivo liver perfusion for the storage, assessment, and repair of marginal liver grafts
JM Knaak, VN Spetzler, N Goldaracena… - JoVE (Journal of …, 2014 - jove.com
The success of liver transplantation has resulted in a dramatic organ shortage. In most
transplant regions 20-30% of patients on the waiting list for liver transplantation die without …
transplant regions 20-30% of patients on the waiting list for liver transplantation die without …
Advantages of normothermic perfusion over cold storage in liver preservation
CJ Imber, SDS Peter, IL de Cenarruzabeitia… - …, 2002 - journals.lww.com
Background. To minimize the ischemia-reperfusion injury that occurs to the liver with the
current method of preservation and transplantation, we have used an extracorporeal circuit …
current method of preservation and transplantation, we have used an extracorporeal circuit …
Ex-vivo normothermic liver perfusion: an update
Avoidance of cold ischaemic preservation damage and repair of injury sustained during
warm ischaemia and organ procurement would potentially allow many livers from extended …
warm ischaemia and organ procurement would potentially allow many livers from extended …
[HTML][HTML] Liver graft preservation methods during cold ischemia phase and normothermic machine perfusion
KY Tchilikidi - World Journal of Gastrointestinal Surgery, 2019 - ncbi.nlm.nih.gov
The growing demand for donor organs requires measures to expand donor pool. Those
include extended criteria donors, such as elderly people, steatotic livers, donation after …
include extended criteria donors, such as elderly people, steatotic livers, donation after …
[HTML][HTML] Liver transplantation after ex vivo normothermic machine preservation: a phase 1 (first-in-man) clinical trial
R Ravikumar, W Jassem, H Mergental, N Heaton… - American Journal of …, 2016 - Elsevier
The number of donor organs suitable for liver transplantation is restricted by cold
preservation and ischemia–reperfusion injury. We present the first patients transplanted …
preservation and ischemia–reperfusion injury. We present the first patients transplanted …
[PDF][PDF] The case for normothermic machine perfusion in liver transplantation
CDL Ceresa, D Nasralla, CC Coussios… - Liver …, 2018 - Wiley Online Library
In recent years, there has been growing interest in normothermic machine perfusion (NMP)
as a preservation method in liver transplantation. In most countries, because of a donor …
as a preservation method in liver transplantation. In most countries, because of a donor …
Perspectives in organ preservation
MHJ Maathuis, HGD Leuvenink, RJ Ploeg - Transplantation, 2007 - journals.lww.com
Maintaining organ viability after donation until transplantation is critically important for
optimal graft function and survival. To date, static cold storage is the most widely used form …
optimal graft function and survival. To date, static cold storage is the most widely used form …
Ex vivo Normothermic Machine Perfusion and Viability Testing of Discarded Human Donor Livers
S Op den Dries, N Karimian, ME Sutton… - American Journal of …, 2013 - Wiley Online Library
In contrast to traditional static cold preservation of donor livers, normothermic machine
perfusion may reduce preservation injury, improve graft viability and potentially allows ex …
perfusion may reduce preservation injury, improve graft viability and potentially allows ex …
[HTML][HTML] Subnormothermic machine perfusion for ex vivo preservation and recovery of the human liver for transplantation
To reduce widespread shortages, attempts are made to use more marginal livers for
transplantation. Many of these grafts are discarded for fear of inferior survival rates or biliary …
transplantation. Many of these grafts are discarded for fear of inferior survival rates or biliary …