Normothermic liver preservation: a new paradigm?

R Ravikumar, H Leuvenink… - Transplant international, 2015 - Wiley Online Library
Despite increasing donor numbers, waiting lists and pre‐transplant mortality continue to
grow in many countries. The number of donor organs suitable for liver transplantation is …

Technique of subnormothermic ex vivo liver perfusion for the storage, assessment, and repair of marginal liver grafts

JM Knaak, VN Spetzler, N Goldaracena… - JoVE (Journal of …, 2014 - jove.com
The success of liver transplantation has resulted in a dramatic organ shortage. In most
transplant regions 20-30% of patients on the waiting list for liver transplantation die without …

Advantages of normothermic perfusion over cold storage in liver preservation

CJ Imber, SDS Peter, IL de Cenarruzabeitia… - …, 2002 - journals.lww.com
Background. To minimize the ischemia-reperfusion injury that occurs to the liver with the
current method of preservation and transplantation, we have used an extracorporeal circuit …

Ex-vivo normothermic liver perfusion: an update

T Vogel, JG Brockmann, PJ Friend - Current opinion in organ …, 2010 - journals.lww.com
Avoidance of cold ischaemic preservation damage and repair of injury sustained during
warm ischaemia and organ procurement would potentially allow many livers from extended …

[HTML][HTML] Liver graft preservation methods during cold ischemia phase and normothermic machine perfusion

KY Tchilikidi - World Journal of Gastrointestinal Surgery, 2019 - ncbi.nlm.nih.gov
The growing demand for donor organs requires measures to expand donor pool. Those
include extended criteria donors, such as elderly people, steatotic livers, donation after …

[HTML][HTML] Liver transplantation after ex vivo normothermic machine preservation: a phase 1 (first-in-man) clinical trial

R Ravikumar, W Jassem, H Mergental, N Heaton… - American Journal of …, 2016 - Elsevier
The number of donor organs suitable for liver transplantation is restricted by cold
preservation and ischemia–reperfusion injury. We present the first patients transplanted …

[PDF][PDF] The case for normothermic machine perfusion in liver transplantation

CDL Ceresa, D Nasralla, CC Coussios… - Liver …, 2018 - Wiley Online Library
In recent years, there has been growing interest in normothermic machine perfusion (NMP)
as a preservation method in liver transplantation. In most countries, because of a donor …

Perspectives in organ preservation

MHJ Maathuis, HGD Leuvenink, RJ Ploeg - Transplantation, 2007 - journals.lww.com
Maintaining organ viability after donation until transplantation is critically important for
optimal graft function and survival. To date, static cold storage is the most widely used form …

Ex vivo Normothermic Machine Perfusion and Viability Testing of Discarded Human Donor Livers

S Op den Dries, N Karimian, ME Sutton… - American Journal of …, 2013 - Wiley Online Library
In contrast to traditional static cold preservation of donor livers, normothermic machine
perfusion may reduce preservation injury, improve graft viability and potentially allows ex …

[HTML][HTML] Subnormothermic machine perfusion for ex vivo preservation and recovery of the human liver for transplantation

BG Bruinsma, H Yeh, S Özer, PN Martins… - American Journal of …, 2014 - Elsevier
To reduce widespread shortages, attempts are made to use more marginal livers for
transplantation. Many of these grafts are discarded for fear of inferior survival rates or biliary …