Normothermic perfusion: a new paradigm for organ preservation

J Brockmann, S Reddy, C Coussios, D Pigott… - Annals of …, 2009 - journals.lww.com
Objective: Transplantation of organs retrieved after cardiac arrest could increase the donor
organ supply. However, the combination of warm ischemia and cold preservation is highly …

Normothermic machine perfusion of donor livers for transplantation in the United States: a randomized controlled trial

WC Chapman, AS Barbas, AM D'Alessandro… - Annals of …, 2023 - journals.lww.com
Objective: To compare conventional low-temperature storage of transplant donor livers
[static cold storage (SCS)] with storage of the organs at physiological body temperature …

Determination and extension of the limits to static cold storage using subnormothermic machine perfusion

BG Bruinsma, TA Berendsen… - … journal of artificial …, 2013 - journals.sagepub.com
Background/Aims Static cold storage (SCS) of the liver for transplantation is limited by time.
Continuation of metabolic activity leads to depletion of energy stores and loss of cellular …

[HTML][HTML] Emerging concepts in liver graft preservation

M Bejaoui, E Pantazi, E Folch-Puy… - World journal of …, 2015 - ncbi.nlm.nih.gov
The urgent need to expand the donor pool in order to attend to the growing demand for liver
transplantation has obliged physicians to consider the use of suboptimal liver grafts and also …

Preservation of porcine non–heart-beating donor livers by sequential cold storage and warm perfusion

SP Reddy, S Bhattacharjya, N Maniakin… - …, 2004 - journals.lww.com
Background. Normothermic perfusion has been shown to resuscitate and maintain viability
of non–heart-beating donor (NHBD) livers that have undergone significant warm ischemic …

[HTML][HTML] Controlled oxygenated rewarming of cold stored liver grafts by thermally graduated machine perfusion prior to reperfusion

T Minor, P Efferz, M Fox, J Wohlschlaeger… - American Journal of …, 2013 - Elsevier
The quality of cold-stored livers declines with the extension of ischemic time, increasing the
risk of primary dys or nonfunction. A new concept to rescue preserved marginal liver grafts …

Sequential cold storage and normothermic perfusion of the ischemic rat liver

H Tolboom, JM Milwid, ML Izamis, K Uygun… - Transplantation …, 2008 - Elsevier
Extending transplant criteria to include livers obtained from donors after cardiac death
(DCD) could increase the liver donor pool, but conventional simple cold storage of these …

Functional human liver preservation and recovery by means of subnormothermic machine perfusion

BG Bruinsma, JH Avruch, PD Weeder… - JoVE (Journal of …, 2015 - jove.com
There is currently a severe shortage of liver grafts available for transplantation. Novel organ
preservation techniques are needed to expand the pool of donor livers. Machine perfusion …

Functional recovery of preserved livers following warm ischemia: improvement by machine perfusion preservation

CY Lee, JX Zhang, JW Jones Jr, JH Southard… - …, 2002 - journals.lww.com
Background. Hypothermic machine perfusion preservation has the potential to relieve the
current donor shortage problem by reclaiming and preserving marginal donor organs …

The influence of storage temperature during machine perfusion on preservation quality of marginal donor livers

P Olschewski, P Gaß, V Ariyakhagorn, K Jasse… - Cryobiology, 2010 - Elsevier
BACKGROUND: Although non-heart-beating donors have the potential to increase the
number of available organs, the livers are used very seldom because of the risk of primary …