Despite some recent declines, cardiovascular disease (CVD) remains the major cause of
death in the United States and worldwide. Most recent advances in the treatment of CVD …

Experimental and clinical studies suggest that oxidative stress contributes to the
development and progression of cardiovascular disease. However, clinical trials with classic …

Over the last two decades, it has become increasingly clear that reactive oxygen species
(ROS), including free radicals are involved in cardiovascular disease. In recent years, there …

Based on the “free radical theory” of disease, researchers have been trying to elucidate the
role of oxidative stress from free radicals in cardiovascular disease. Considerable data …

Multiple factors are involved in the etiology of cardiovascular disease (CVD). Pathological
changes occur in a variety of cell types long before symptoms become apparent and …

According to the latest Global Burden of Disease Study data, non-communicable diseases in
general and cardiovascular disease (CVD) in particular are the leading cause of premature …

Growing evidence indicates that chronic and acute overproduction of reactive oxygen
species (ROS) under pathophysiologic conditions is integral in the development of …

Reactive oxygen species (ROS) are subcellular messengers in signal transductions
pathways with both beneficial and deleterious roles. ROS are generated as a by-product of …

The body of current evidence from in vitro studies indicates that oxidative stress plays a
major role in cardiovascular disease but the details of molecular events in vivo and in …

Production of considerable amounts of reactive oxygen species (ROS) eventually leads to
oxidative stress. A key role of oxidative stress is evident in the pathologic mechanisms of …