CD40L plays a major role in immune response and is a major therapeutic target for
inflammation. Integrin α5β1 and CD40 simultaneously bind to CD40L. It is unclear if α5β1 …

CD40L is a member of the TNF superfamily that participates in immune cell activation. It
binds to and signals through several integrins, including αvβ3 and α5β1, which bind to the …

It was originally thought that the critical role of the CD40 ligand (CD40L) in normal and
inflammatory immune responses was mainly mediated through its interaction with the classic …

CD40L is expressed in activated T cells, and it plays a major role in immune response and is
a major therapeutic target for inflammation. High IgM syndrome type 1 (HIGM1) is a …

For several years, the primary function of CD40 ligand (CD40L) has been believed to be in
regulation of contact-dependent, CD40-CD40L-mediated signals between B-and T-cells …

In addition to its classical CD40 receptor, CD154 also binds to αIIbβ3, α5β1, and αMβ2
integrins. Binding of CD154 to these receptors seems to play a key role in the pathogenic …

Abstract CD40 ligand (CD40L) is a 33 kDa type II glycoprotein which is transiently
expressed on the surface of T cells following activation. The demonstration that signals …

CD40 is a cell surface receptor that belongs to the tumor necrosis factor‐R (TNF‐R) family,
and that was first identified and functionally characterized on B lymphocytes. Its critical role …

We report the characterization of a naturally occurring polymorphism in CD40 ligand
(CD40L, CD154) expressed by activated T cells from a young female patient. This …

Signals delivered to B cells through CD40 are critical to the development of humoral
immune responses. In this study we characterize regions of the 62-amino acid cytoplasmic …