The absence of pathological hallmarks of progressive multiple sclerosis (MS) in commonly
used rodent models of experimental autoimmune encephalomyelitis (EAE) hinders the …

Multiple sclerosis (MS) is the most common cause for sustained disability in young adults,
yet treatment options remain very limited. Although numerous therapeutic approaches have …

Background Experimental autoimmune encephalomyelitis (EAE) in the common marmoset
monkey (Callithrix jacchus) is a relevant preclinical model for translational research into …

Introduction Multiple sclerosis (MS) is an enigmatic autoimmune‐driven inflammatory/
demyelinating disease of the human central nervous system (CNS), affecting brain, spinal …

Background While many groups use experimental autoimmune encephalomyelitis (EAE) as
a model to uncover therapeutic targets and understand the pathology underlying multiple …

The experimental autoimmune encephalitis (EAE) model is used for preclinical research into
the pathogenesis of multiple sclerosis (MS), mostly in inbred, specific pathogen free (SPF) …

Aging Western societies are facing an increasing prevalence of chronic autoimmune-
mediated inflammatory disorders (AIMIDs) for which treatments that are safe and effective …

In view of disease heterogeneity of multiple sclerosis and limited access to ex vivo
specimens, different approaches must be undertaken to better understand disease …

Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis
(MS) that has shaped our understanding of autoimmune tissue inflammation in the central …

The attrition rate of new drugs for central nervous system diseases including multiple
sclerosis (MS) is very high. A widely recognized bottleneck in the selection of promising …