The effect of encapsulated apigenin nanoparticles on HePG-2 cells through regulation of P53

MM Mabrouk Zayed, HA Sahyon, NAN Hanafy… - Pharmaceutics, 2022 - mdpi.com
Apigenin (Ap) is one of the most important natural flavonoids that has potent anticancer
activity. This study was designed, for the first time, to load Ap into chitosan to improve its …

Apigenin loaded nanoparticle delayed development of hepatocellular carcinoma in rats

S Bhattacharya, L Mondal, B Mukherjee, L Dutta… - … , Biology and Medicine, 2018 - Elsevier
Hepatocellular carcinoma (HCC) is one of the major causes of cancer related death globally.
Apigenin, a dietary flavonoid, possesses anti-tumor activity against HCC cells in-vitro …

Preparation, characterization and antitumor activity evaluation of apigenin nanoparticles by the liquid antisolvent precipitation technique

W Wu, Y Zu, L Wang, L Wang, H Wang, Y Li, M Wu… - Drug …, 2017 - Taylor & Francis
The present work aimed to apply the liquid antisolvent precipitation (LAP) method for
preparing the apigenin nanoparticles and thereby improving the solubility and bioavailability …

Nanoencapsulation of apigenin with whey protein isolate: Physicochemical properties, in vitro activity against colorectal cancer cells, and bioavailability

S Hong, VP Dia, SJ Baek, Q Zhong - Lwt, 2022 - Elsevier
Incorporating lipophilic phytochemicals with anti-cancer activities in functional beverages
requires an appropriate nanoencapsulation technology. The present objective was to …

Apigenin-loaded galactose tailored PLGA nanoparticles: A possible strategy for liver targeting to treat hepatocellular carcinoma

S Ganguly, S Dewanjee, R Sen… - Colloids and Surfaces B …, 2021 - Elsevier
Hepatocellular carcinoma (HCC) is the most common hepatic malignancy worldwide.
Recent reports focusing on the efficacy of apigenin-loaded nanoparticles (NPs) in combating …

Apigenin in cancer therapy: From mechanism of action to nano-therapeutic agent

Y Zhou, Y Yu, H Lv, H Zhang, T Liang, G Zhou… - Food and Chemical …, 2022 - Elsevier
Apigenin (APG) is a flavonoid presence in beverages, vegetables, and fruits containing anti-
diabetic, anti-oxidant, and anti-viral activities, as well as cancer management properties …

Formulation and evaluation of apigenin-loaded hybrid nanoparticles

I Kazmi, FA Al-Abbasi, SS Imam, M Afzal, MS Nadeem… - Pharmaceutics, 2022 - mdpi.com
Apigenin (AGN) is a potent phytochemical with strong antioxidant and anticancer potential.
But its therapeutic efficacy is limited due to its high lipophilic characteristics. Therefore, the …

Anti-proliferative effect of apigenin and its apoptotic induction in human Hep G2 cells

LC Chiang, LT Ng, IC Lin, PL Kuo, CC Lin - Cancer letters, 2006 - Elsevier
Apigenin, a common dietary flavonoid abundantly present in fruits and vegetables, is
believed to possess preventive and therapeutic potential against cancers. In this study, the …

Development and optimization of hybrid polymeric nanoparticles of apigenin: Physicochemical characterization, antioxidant activity and cytotoxicity evaluation

A Zafar, NK Alruwaili, SS Imam, OA Alsaidan… - Sensors, 2022 - mdpi.com
Breast cancer is the most common cancer in females and ranked second after skin cancer.
The use of natural compounds is a good alternative for the treatment of breast cancer with …

Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells

PW Zheng, LC Chiang, CC Lin - Life sciences, 2005 - Elsevier
Apigenin is a widely distributed plant flavonoid and was proposed as an antitumor agent. In
this study, we reported for the first time that apigenin inhibited the growth of human cervical …