Hyperuricemia has been recognized as a risk factor for insulin resistance as well as one of
the factors leading to diabetic kidney disease (DKD). Since DKD is the most common cause …

Background: Oxidative stress and inflammation are known to play central roles in the
development of diabetic nephropathy (DN). Febuxostat is a novel non-purine xanthine …

Background and Purpose Elevated serum uric acid (UA) is a risk factor for the development
of kidney disease. Inhibitors of xanthine oxidase (XOi), an enzyme involved in UA synthesis …

Recent clinical studies have demonstrated the protective effect of xanthine oxidase (XO)
inhibitors against chronic kidney diseases, although the underlying molecular mechanisms …

Xanthine oxidase (XO) is an important source of reactive oxygen species. This study
investigated whether XO inhibition exerts renoprotective effects by inhibiting vascular …

Although hyperuricemia has been shown to be associated with the progression of
cardiovascular disorder and chronic kidney disease (CKD), there is conflicting evidence as …

Endothelial dysfunction represents a predominant early feature of diabetes, rendering
patients with diabetes prone to renal complications, eg, proteinuria. Recent studies have …

Hyperuricemia has recently been recognized to be a risk factor for nephropathy in the
diabetic subject. We tested the hypothesis that lowering uric acid with a xanthine oxidase …

Chronic stress is closely linked to the metabolic syndrome, diabetes, hyperuricemia and
thromboembolism, but the mechanisms remain elusive. We reported recently that stress …

Xanthine oxidase (XO) is an enzyme responsible for the production of uric acid. XO
produces considerable amount of oxidative stress throughout the body. To date, however, its …