A key question in addiction research concerns how, in some individuals, initial recreational
or casual patterns of drug use may change brain and psychological function in ways that …

The temporal pattern of drug use (pharmacokinetics) has a profound effect on the ability of
self‐administered cocaine to produce addiction‐like behavior in rodents, and to change the …

The chronic and relapsing nature of addiction suggests that drugs produce persistent
adaptations in the brain that make individuals with drug addiction particularly sensitive to …

Recent attempts to model the addiction process in rodents have focused on cocaine self-
administration procedures that provide extended daily access. Such procedures produce a …

The rapid delivery of drugs of abuse to the brain is associated with an increased likelihood
and severity of addiction. Here we evaluated the hypothesis that rapidly delivered cocaine …

Rationale It has long been hypothesized that human as well as animal cocaine users titrate
their intake to maintain a specific level of cocaine reward. This hypothesis predicts that the …

Cocaine self-administration provides a methodology allowing researchers to study changes
in distinct aspects of drug-taking behavior that model behaviors observed in drug addicts …

It has been asserted that any comprehensive understanding of cocaine abuse and its
treatment will require attention to both behavioral and pharmacological variables. Although …

How much, how often and how fast a drug reaches the brain determine the behavioural and
neuroplastic changes associated with the addiction process. Despite the critical nature of …

Rationale The transition from initial drug use to drug addiction has been proposed to result
from an allostatic decrease in reward function driven by an overactivation of brain antireward …