[HTML][HTML] Evaluation of antitumor activity of survivin short interfering RNA delivered by lipid nanoparticles in colon cancer in vitro and in vivo

T Wang, Z Liu, Z Zhang, S Tang, M Yue… - Oncology …, 2017 - spandidos-publications.com
Survivin has been overexpressed in numerous types of cancer and is associated with a poor
clinical outcome. A number of various approaches have been used to counteract survivin in …

Survivin downregulation using siRNA nanoliposomes inhibits cell proliferation and promotes the apoptosis of MHCC-97H hepatic cancer cells: An in vitro and in vivo …

Z Liu, T Wang, Z Zhang, S Tang, S Feng… - Oncology …, 2017 - spandidos-publications.com
At present, survivin is one of the most cancer-specific proteins that has been identified. The
present study aimed to investigate the antitumor effects of novel survivin small interfering …

Novel survivin-targeted small interfering RNA delivered by nanoparticles

C Feng, T Wang, Y Zhang, K Qu, S Tang - The American journal of the …, 2017 - Elsevier
Background The aim of the present study was to investigate the antitumor effect of our novel
survivin-targeted small interfering RNA (siRNA) nanoliposomes on xenograft mouse models …

[HTML][HTML] Small interfering RNA targeting of the survivin gene inhibits human tumor cell growth in vitro

Z Zhang, T Wang, Z Liu, S Tang… - Experimental and …, 2017 - spandidos-publications.com
The present study aimed to evaluate the impact of small interfering RNA (siRNA) targeting of
the survivin gene in human tumor cells and the effect of decreased survivin expression on …

[HTML][HTML] Oncolytic adenovirus mediated Survivin knockdown by RNA interference suppresses human colorectal carcinoma growth in vitro and in vivo

W Shen, CY Wang, XH Wang, ZX Fu - Journal of Experimental & Clinical …, 2009 - Springer
Background Colorectal cancer is a one of the most common alimentary malignancies.
Survivin has been proved by many studies to be an ideal target for cancer gene therapy …

Introduction of a survivin gene-specific small inhibitory RNA inhibits growth of pancreatic cancer cells

N Tsuji, K Asanuma, D Kobayashi… - Anticancer …, 2005 - ar.iiarjournals.org
Background: The anti-apoptotic molecule survivin is expressed in human cancers of various
origins. Since this molecule possesses multiple functions, including apoptosis inhibition, cell …

Topotecan and small interfering RNA suppress survivin expression synergistically in Caki-1 renal cancer cells: Direct suppression of survivin and enhancement of …

A Sato, K Ito, T Asano, M Sumitomo… - International …, 2008 - spandidos-publications.com
Survivin is an apoptosis inhibitor found in many tumors but not in most normal differentiated
tissues, which makes it an exciting target for cancer therapy. Survivin expression has been …

[PDF][PDF] Inhibitory effect of survivin-targeting small interfering RNA on gastric cancer cells

YH Li, M Chen, M Zhang, XQ Zhang, S Zhang… - Genet Mol …, 2014 - geneticsmr.com
A pair of inverted repeated sequences of the gene survivin was designed for stable double-
stranded RNA establishment. After stable transfection, the biological behaviors of gastric …

[HTML][HTML] Survivin antisense compound inhibits proliferation and promotes apoptosis in liver cancer cells

DJ Dai, CD Lu, RY Lai, JM Guo, H Meng… - World Journal of …, 2005 - ncbi.nlm.nih.gov
AIM: To evaluate the effects of survivin on cell proliferation and apoptosis in liver cancer.
METHODS: MTT assay was used to generate and optimize phosphorothioate antisense …

[HTML][HTML] Downregulation of survivin by RNAi inhibits growth of human gastric carcinoma cells

GY Miao, QM Lu, XL Zhang - World Journal of Gastroenterology …, 2007 - ncbi.nlm.nih.gov
AIM: To investigate the inhibitory effect of a specific small survivin interfering RNA (siRNA)
on cell proliferation and the expression of survivin in human gastric carcinoma cell line SGC …