The gut microbiome, immunity, and Plasmodium severity

ML Waide, NW Schmidt - Current opinion in microbiology, 2020 - Elsevier
Highlights•Gut microbiota is associated with malaria in rodents and humans.•Gut microbiota
influences systemic adaptive immune responses.•Probiotic treatment in infants can …

[引用][C] Enhancing pathogen resistance: the gut microbiota and malaria

JM Moore, JCM Aparicio - 2022 - Elsevier

High-risk microbial signatures are associated with severe parasitemia in controlled Plasmodium infections of both humans and rhesus macaques

AT Gustin, CA Broedlow, K Hager, E Coronado… - bioRxiv, 2022 - biorxiv.org
While functions of the gastrointestinal (GI) microbiome include maintenance of immune
homeostasis and protection against infectious disease, its role in determining disease …

Malaria disrupts the rhesus macaque gut microbiome

DN Farinella, S Kaur, VL Tran… - Frontiers in Cellular …, 2023 - frontiersin.org
Previous studies have suggested that a relationship exists between severity and
transmissibility of malaria and variations in the gut microbiome, yet only limited information …

Insights into malaria pathogenesis gained from host metabolomics

HN Colvin, R Joice Cordy - PLoS Pathogens, 2020 - journals.plos.org
Malaria is a devastating disease caused by the protozoan parasite Plasmodium. The most
common Plasmodium species that infect humans are Plasmodium falciparum and …

[HTML][HTML] Susceptibility to febrile malaria is associated with an inflammatory gut microbiome

N Schmidt, K Van Den Ham, L Bower, S Li… - Research …, 2024 - ncbi.nlm.nih.gov
Malaria is a major public health problem, but many of the factors underlying the
pathogenesis of this disease are not well understood. Here, we demonstrate in Malian …

Stool microbiota composition is associated with the prospective risk of Plasmodium falciparum infection

S Yooseph, EF Kirkness, TM Tran, DM Harkins… - BMC genomics, 2015 - Springer
Background In humans it is unknown if the composition of the gut microbiota alters the risk of
Plasmodium falciparum infection or the risk of developing febrile malaria once P. falciparum …

Gut microbiota composition modulates the magnitude and quality of germinal centers during Plasmodium infections

ML Waide, R Polidoro, WL Powell, JE Denny, J Kos… - Cell reports, 2020 - cell.com
Gut microbiota composition is associated with human and rodent Plasmodium infections, yet
the mechanism by which gut microbiota affects the severity of malaria remains unknown …

Identifying the Components of Acidosis in Patients With Severe Plasmodium falciparum Malaria Using Metabolomics

SJ Leopold, A Ghose, EL Allman… - The Journal of …, 2019 - academic.oup.com
Abstract Background Acidosis in severe Plasmodium falciparum malaria is associated with
high mortality, yet the pathogenesis remains incompletely understood. The aim of this study …

An Overview on the Impact of Microbiota on Malaria Transmission and Severity: Plasmodium–Vector–Host Axis

ZN Omondi, A Caner - Acta Parasitologica, 2022 - Springer
Purpose Malaria, which is a vector-borne disease caused by Plasmodium sp., continue to
become a serious threat, causing more than 600,000 deaths annually, especially in …