The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism.
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular …

Angiogenesis is a key enabling feature of mammalian embryonic development and tumor
progression, which provides oxygen and nutrients that are required for vessel growth and …

Effective vascular regeneration could provide therapeutic benefit for multiple pathologies,
especially in chronic peripheral artery disease (PAD) and myocardial ischemia. The hypoxia …

Hypoxia is a state where oxygen availability/delivery is below the level necessary to
maintain physiological oxygen tension for a particular tissue. It is well-established that when …

When tissue perfusion is impaired, the resulting reduction in O2 availability activates
hypoxia-inducible factor 1 (HIF-1), which mediates increased transcription of genes …

Blood vessels function as conduits for the delivery of O2 and nutrients. Hypoxia-inducible
factor 1 (HIF-1) mediates adaptive transcriptional responses to hypoxia/ischemia that …

Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in
ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified …

The cardiovascular system ensures the delivery of oxygen and nutrients to all cells, tissues,
and organs. Under extended exposure to reduced oxygen levels, cells are able to survive …

Atherosclerosis is a highly prevalent disease that can significantly increase the risk of major
vascular events, such as myocardial or cerebral infarctions. The anoxemia theory states that …

Localized tissue hypoxia is a consequence of vascular compromise or rapid cellular
proliferation and is a potent inducer of compensatory angiogenesis. The oxygen-responsive …