The endoplasmic reticulum (ER) has emerged as a source of hydrogen peroxide (H2O2)
and a hub for peroxide-based signaling events. Here we outline cellular sources of ER …

Cellular metabolism is inherently linked to the production of oxidizing by-products, including
reactive oxygen species (ROS) hydrogen peroxide (H 2 O 2). When present in excess, H 2 O …

Oxidative protein folding in the endoplasmic reticulum (ER) is a significant source of
hydrogen peroxide (H 2 O 2). For correct protein folding the redox state of the ER must be …

Disulphide formation within the endoplasmic reticulum (ER) requires the activity of the ER
oxidase Ero1, and as a consequence, generates hydrogen peroxide. The production of …

Oxidative protein folding in the endoplasmic reticulum (ER) has emerged as a potentially
significant source of cellular reactive oxygen species (ROS). Recent studies suggest that …

The endoplasmic reticulum (ER) is an essential organelle of eukaryotic cells. Its main
functions include protein synthesis, proper protein folding, protein modification, and the …

The endoplasmic reticulum (ER) provides an environment optimized for oxidative protein
folding through the action of Ero1p, which generates disulfide bonds, and Pdi1p, which …

Significance: The endoplasmic reticulum (ER), the port of entry into the secretory pathway, is
a complex organelle that performs many fundamental functions, including protein synthesis …

The endoplasmic reticulum (ER) plays a major role in regulating synthesis, folding, and
orderly transport of proteins. It is also essentially involved in various cellular signaling …

The endoplasmic reticulum (ER) is a dynamic organelle responsible for many cellular
functions in eukaryotic cells. Proper redox conditions in the ER are necessary for the …