[HTML][HTML] Neohesperidin dihydrochalcone and neohesperidin dihydrochalcone-O-glycoside attenuate subcutaneous fat and lipid accumulation by regulating PI3K/AKT …

M Kwon, Y Kim, J Lee, JA Manthey, Y Kim, Y Kim - Nutrients, 2022 - mdpi.com
Neohesperidin dihydrochalcone (NHDC), a semi-natural compound from bitter orange, is an
intense sweetener. The anti-obesity effects of NHDC and its glycosidic compound, NHDC-O …

[HTML][HTML] Phyllodulcin, a natural sweetener, regulates obesity-related metabolic changes and fat browning-related genes of subcutaneous white adipose tissue in high …

E Kim, SM Lim, MS Kim, SH Yoo, Y Kim - Nutrients, 2017 - mdpi.com
Phyllodulcin is a natural sweetener found in Hydrangea macrophylla var. thunbergii. This
study investigated whether phyllodulcin could improve metabolic abnormalities in high-fat …

Antidiabetic‐Like Effects of Naringenin‐7‐O‐glucoside from Edible Chrysanthemum 'Kotobuki' and Naringenin by Activation of the PI3K/Akt Pathway and PPARγ

A Nishina, D Sato, J Yamamoto… - Chemistry & …, 2019 - Wiley Online Library
Obesity is directly associated with cancer, cardiovascular injury, hypertension, and type 2
diabetes. To date, Yamamoto identified that hot water extracts of edible Chrysanthemum …

[HTML][HTML] Green tea polyphenols reduce body weight in rats by modulating obesity-related genes

C Lu, W Zhu, CL Shen, W Gao - PloS one, 2012 - journals.plos.org
Beneficial effects of green tea polyphenols (GTP) against obesity have been reported,
however, the mechanism of this protection is not clear. Therefore, the objective of this study …

[HTML][HTML] Pentamethylquercetin regulates lipid metabolism by modulating skeletal muscle-adipose tissue crosstalk in obese mice

J Wu, J Du, Z Li, W He, M Wang, M Jin, L Yang, H Liu - Pharmaceutics, 2022 - mdpi.com
Irisin is an exercise-induced hormone that regulates lipid metabolism. The present study
investigates whether the anti-obesity effect of the natural flavonoid pentamethylquercetin …

p‐Synephrine exhibits anti‐adipogenic activity by activating the Akt/GSK3β signaling pathway in 3T3‐L1 adipocytes

LX Guo, G Chen, ZY Yin, YH Zhang… - Journal of food …, 2019 - Wiley Online Library
This work aimed to investigate the effects of p‐synephrine on the differentiation of adipocyte
and explore the underlying mechanism. We found that p‐synephrine suppressed the 3T3 …

[HTML][HTML] Tea polyphenol EGCG ameliorates obesity-related complications by regulating lipidomic pathway in leptin receptor knockout rats

G Wu, H Cheng, H Guo, Z Li, D Li, Z Xie - The Journal of Nutritional …, 2023 - Elsevier
Abstract Tea polyphenol epigallocatechin-3-gallate (EGCG) has been widely recognized for
antiobesity effects. However, the molecular mechanism of lipidomic pathway related to lipid …

Anti-obese effects and signaling mechanisms of Chaenomeles sinensis extracts in 3T3-L1 preadipocytes and obese mice fed a high-fat diet

DH Kim, B Kwon, SJ Kim, HJ Kim, SI Jeong… - Herbal Formula …, 2017 - koreascience.kr
Obesity is one of the most serious health problem because it induced numerous metabolic
syndrome and increases the incidence of various disease, including diabetes, hypertension …

[HTML][HTML] Effects of neohesperidin dihydrochalcone (NHDC) on oxidative phosphorylation, cytokine production, and lipid deposition

S Choi, S Yu, J Lee, W Kim - Foods, 2021 - mdpi.com
The sweetener neohesperidin dihydrochalcone (NHDC) is a precursor for anthocyanins and
has been reported to have various bioactivities, including antioxidant and hepatitis inhibitory …

Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-A y mice

S Jia, Y Hu, W Zhang, X Zhao, Y Chen, C Sun, X Li… - Food & Function, 2015 - pubs.rsc.org
The present study is to investigate the possible hypoglycemic and hypolipidemic effects of
neohesperidin (NHP) derived from Citrus aurantium L. in vivo. KK-Ay mice were used as the …