In this study, we split 2156 individuals from the Chinese Longitudinal Healthy Longevity
Survey (CLHLS) data into two groups, establishing a phenotype of exceptional longevity & …

Background We previously demonstrated familial aggregation of memory performance
within the Long Life Family Study (LLFS), suggesting that exceptional cognition (EC) may …

Like most complex phenotypes, exceptional longevity is thought to reflect a combined
influence of environmental (eg, lifestyle choices, where we live) and genetic factors. To …

Studies investigating exceptionally long-lived (ELL) individuals, including genetic studies,
have linked cardiovascular-related pathways, particularly lipid and cholesterol homeostasis …

Background Many factors contribute to exceptional longevity, with genetics playing a
significant role. However, to date, genetic studies examining exceptional longevity have …

Genetic influences have an important role in the ageing process. The genetic factors that
influence success in bodily ageing may also contribute to the successful ageing of cognitive …

There is growing interest in studying the genetic contributions to longevity, but limited
relevant genes have been identified. In this study, we performed a genetic association study …

Despite evidence from family studies that there is a strong genetic influence upon
exceptional longevity, relatively few genetic variants have been associated with this trait …

Longevity was influenced by many complex diseases and traits. However, the relationships
between human longevity and genetic risks of complex diseases were not broadly studied …

Subjects with exceptional longevity have a lower incidence and/or significant delay in the
onset of age-related disease, and their family members may inherit biological factors that …