[HTML][HTML] Family matters in unraveling human longevity
N van den Berg - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Niels van den Berg www. aging-us. com AGING 2020, Vol. 12, No. 22 www. aging-us. com
22354 AGING and socio-behavioral and environmental components (G x E interactions). To …
22354 AGING and socio-behavioral and environmental components (G x E interactions). To …
Effect of longevity genetic variants on the molecular aging rate
We conducted a genome-wide association study of 1320 centenarians from the New
England Centenarian Study (median age= 104 years) and 2899 unrelated controls using> 9 …
England Centenarian Study (median age= 104 years) and 2899 unrelated controls using> 9 …
Genome‐wide linkage analysis for human longevity: Genetics of Healthy Aging Study
Clear evidence exists for heritability of human longevity, and much interest is focused on
identifying genes associated with longer lives. To identify such longevity alleles, we …
identifying genes associated with longer lives. To identify such longevity alleles, we …
[HTML][HTML] The influence of gender on inheritance of exceptional longevity
JA Deluty, G Atzmon, J Crandall, N Barzilai… - Aging (Albany …, 2015 - ncbi.nlm.nih.gov
While the search for genetic contributors to exceptional longevity has yielded candidates,
gender differences in inheritance have generally not been considered. The aim of this study …
gender differences in inheritance have generally not been considered. The aim of this study …
[HTML][HTML] The reduction of vascular disease risk mutations contributes to longevity in the Chinese population
Aim Genetic factors play important roles in determining human lifespan. Although some
“longevity genes” have been identified to be implicated in human longevity, many disease …
“longevity genes” have been identified to be implicated in human longevity, many disease …
Exceptional human longevity
RJ Pignolo - Mayo Clinic Proceedings, 2019 - Elsevier
Exceptional longevity represents an extreme phenotype. Current centenarians are survivors
of a cohort who display delayed onset of age-related diseases and/or resistance to …
of a cohort who display delayed onset of age-related diseases and/or resistance to …
[HTML][HTML] Systemic inflammation in relation to exceptional memory in the Long Life Family Study (LLFS)
R Patel, S Cosentino, EZ Zheng, N Schupf… - Brain, Behavior, & …, 2024 - Elsevier
Background and objectives We previously found a substantial familial aggregation of
healthy aging phenotypes, including exceptional memory (EM) in long-lived persons. In the …
healthy aging phenotypes, including exceptional memory (EM) in long-lived persons. In the …
[HTML][HTML] Multi-omics Integration Identifies Genes Influencing Traits Associated with Cardiovascular Risks: The Long Life Family Study
Abstract The Long Life Family Study (LLFS) enrolled 4,953 participants in 539 pedigrees
displaying exceptional longevity. To identify genetic mechanisms that affect cardiovascular …
displaying exceptional longevity. To identify genetic mechanisms that affect cardiovascular …
GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy
L Broer, AS Buchman, J Deelen… - … Series A: Biomedical …, 2015 - academic.oup.com
Background. The genetic contribution to longevity in humans has been estimated to range
from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with …
from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with …
[HTML][HTML] Genetic scores for predicting longevity in the Croatian oldest-old population
Longevity is a hallmark of successful ageing and a complex trait with a significant genetic
component. In this study, 43 single nucleotide polymorphisms (SNPs) were chosen from the …
component. In this study, 43 single nucleotide polymorphisms (SNPs) were chosen from the …