Endothelins are a family of peptides, which comprises endothelin-1 (ET-1), endothelin-2 (ET-
2) and endothelin-3 (ET-3), each containing 21 amino-acids. ET-1 is a peptide secreted …

The endothelins are a family of endothelium-derived peptides that possess characteristically
sustained vasoconstrictor properties. Endothelin-1 appears to be the predominant member …

Endothelins including its most abundant isoform, endothelin-1 (ET-1), are peptides acting as
vasoconstrictors when binding to ET A and ET B receptors, and, in addition to their distinct …

Endothelins (ET-1, ET-2 and ET-3) are a family of 21 amino acid peptides produced by
endothelial cells. They are thought to regulate the local vasomotor tone with endothelium …

Endothelin was isolated and identified in 1988 by Yanagisawa et al. The endothelin family
consists of 21 amino acid isoforms endothelin-1, endothelin-2 and endothelin-3. Endothelin …

Endothelins are powerful vasoconstrictor peptides that also play numerous other functions in
many different organs. Endothelin-1 (ET-1) is the most abundant and important of this family …

Endothelins are ubiquitously produced 21-amino-acid peptides that were discovered as an
endothelial product and may play important roles in cardiovascular physiology and …

The normal functional state of the vasculature and the events leading to the development of
significant arterial disease involve the interaction of important vasoactive substances, which …

Abstract Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide and regulator of blood
flow that plays an important role in blood pressure (BP) elevation in some models of …

Endothelin-1 is a recently discovered peptide mainly released from endothelial cells.
Hypoxia and ischemia as well as numerous factors such as angiotensin 11, thrombin and …