Corynebacterium glutamicum has been used since several decades for the large-scale
production of amino acids, esp. l-glutamate and L-lysine. After initial successes of random …

The amino acid L-lysine is produced on a large scale using mutants of Corynebacterium
glutamicum. However, as yet recombinant DNA techniques have not succeed in improving …

Abstract l-lysine is made in an exceptional large quantity of currently 2,200,000 tons/year
and belongs therefore to one of the leading biotechnological products. Production is done …

Here, we describe the development of a genetically defined strain of l-lysine hyperproducing
Corynebacterium glutamicum by systems metabolic engineering of the wild type …

Abstract l-Lysine has been manufactured using Corynebacterium glutamicum for more than
40 years. Nowadays production exceeds 600,000 tons per year. Based on conventionally …

Carbohydrates exclusively serve as feedstock for industrial amino acid production with
Corynebacterium glutamicum. Due to the industrial interest, knowledge about the pathways …

Classical whole-cell mutagenesis has achieved great success in development of many
industrial fermentation strains, but has the serious disadvantage of accumulation of …

In the present work, metabolic flux engineering of Corynebacterium glutamicum was carried
out to increase lysine production. The strategy focused on engineering of the pentose …

Abstract The Gram-positive bacterium Corynebacterium glutamicum is used for the industrial
production of amino acids, eg of L-glutamate and L-lysine. During the last 15 years, genetic …

Intracellular precursor supply is a critical factor for amino acid productivity of
Corynebacterium glutamicum. To test for the effect of improved pyruvate availability on l …