[HTML][HTML] Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders

NE Omori, MK Malys, G Woo, L Mansor - Frontiers in Psychiatry, 2023 - frontiersin.org
In recent times, advances in the field of metabolomics have shed greater light on the role of
metabolic disturbances in neuropsychiatric conditions. The following review explores the …

[HTML][HTML] Therapeutic potential of exogenous ketone supplement induced ketosis in the treatment of psychiatric disorders: review of current literature

Z Kovács, DP D'Agostino, D Diamond, MS Kindy… - Frontiers in …, 2019 - frontiersin.org
Globally, psychiatric disorders, such as anxiety disorder, bipolar disorder, schizophrenia,
depression, autism spectrum disorder, and attention-deficit/hyperactivity disorder (ADHD) …

[HTML][HTML] Ketogenic-Mimicking Diet as a Therapeutic Modality for Bipolar Disorder: Biomechanistic Rationale and Protocol for a Pilot Clinical Trial

JLB Bohnen, TP Wigstrom, AM Griggs, S Roytman… - Nutrients, 2023 - mdpi.com
There is growing interest in the investigation of ketogenic diets as a potential therapy for
bipolar disorder. The overlapping pharmacotherapies utilized for both bipolar disorder and …

[HTML][HTML] Sleep, mood disorders, and the ketogenic diet: potential therapeutic targets for bipolar disorder and schizophrenia

J Choi, J Kang, T Kim, CJ Nehs - Frontiers in Psychiatry, 2024 - frontiersin.org
Bipolar disorder and schizophrenia are serious psychiatric conditions that cause a
significant reduction in quality of life and shortened life expectancy. Treatments including …

[HTML][HTML] Ketogenic therapy for major depressive disorder: A review of neurobiological evidence

D Shamshtein, T Liwinski - Recent Progress in Nutrition, 2022 - lidsen.com
Major depressive disorder (MDD) is a debilitating illness that places a great burden on
global health. A ketogenic diet, which has traditionally been used for treating refractory …

[HTML][HTML] The evolution of ketosis: potential impact on clinical conditions

LN Dilliraj, G Schiuma, D Lara, G Strazzabosco… - Nutrients, 2022 - mdpi.com
Ketone bodies are small compounds derived from fatty acids that behave as an alternative
mitochondrial energy source when insulin levels are low, such as during fasting or …

Induced ketosis as a treatment for neuroprogressive disorders: food for thought?

G Morris, BK Puri, A Carvalho, M Maes… - International Journal …, 2020 - academic.oup.com
Induced ketosis (or ketone body ingestion) can ameliorate several changes associated with
neuroprogressive disorders, including schizophrenia, bipolar disorder, and major …

Ketogenic Diet and Inflammation: Implications for Mood and Anxiety Disorders

R El Karkafi, T Gebara, M Salem, J Kamel… - … , Gut-Brain Axis and …, 2023 - Springer
The ketogenic diet, known as a low-carbohydrate, high-protein, and high-fat diet, drastically
restrains the major source of energy for the body, forcing it to burn all excess fat through a …

[HTML][HTML] Comparative metabolomic analysis in plasma and cerebrospinal fluid of humans and in plasma and brain of mice following antidepressant-dose ketamine …

R Moaddel, P Zanos, CA Farmer, B Kadriu… - Translational …, 2022 - nature.com
Subanesthetic-dose racemic (R, S)-ketamine (ketamine) produces rapid, robust, and
sustained antidepressant effects in major depressive disorder (MDD) and bipolar disorder …

[HTML][HTML] Effects of ketone bodies on brain metabolism and function in neurodegenerative diseases

NJ Jensen, HZ Wodschow, M Nilsson… - International journal of …, 2020 - mdpi.com
Under normal physiological conditions the brain primarily utilizes glucose for ATP
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …