Kumulární buňky vznikají v ovariálních folikulech diferenciací ze somatických granulózních
buněk. Jsou uspořádány kolem oocytů ve stratifikovaných shlucích, jejichž nejspodnější …

Granulosa cells (GCs) are somatic cells essential for establishing and maintaining bi-
directional communication with the oocytes. This connection has a profound importance for …

STUDY QUESTION Do human granulosa cells (GCs) ingest and destroy apoptotic oocytes?
SUMMARY ANSWER Somatic GCs ingest and destroy apoptotic oocytes and other …

The fixed primordial follicles pool theory, which monopolized reproductive medicine for more
than one hundred years, has been broken by the discovery, successful isolation and …

The ovarian follicle represents the basic functional unit of the ovary and consists of an
oocyte, which is surrounded by granulosa cells (GCs). GCs play an important role in the …

Mammalian follicles are constituted of a complex structure composed of several layers of
granulosa cells surrounding the oocyte and of theca cells that reside beneath its basement …

In the mammalian ovary, each oocyte grows and develops within its own structural and
developmental niche—the follicle. Together with the female germ cell in the follicle are …

Like bell-bottoms and The Beatles in the 1960s, the rage of the day here in the new
millennium has become stem cells. Unlike the Cultural Revolution 40 years ago, stem cell …

Oocyte metabolism reflects other aspects of the unique biology of this important cell type.
The protracted process of mammalian oo genesis exacts a huge metabolic toll on the …

Background In ammatory state within the ovaries can disrupt normal follicular dynamics,
leading to reduced oocyte quality and infertility. In ammatory genes expressed by human …