The non-receptor focal adhesion kinase (FAK) is highly expressed in the central nervous
system during development, where it regulates neurite outgrowth and axon guidance, but its …

Brain disorders are now identified as one of the largest and costliest health risks throughout
human life. While most brain disorders are not life threatening per se, their chronic and …

Focal adhesion kinase (FAK), a non-receptor protein kinase, is known to be a phosphatidyl
inositol 3-kinase (PI3K) pathway activator and thus widely implicated in regulation of cell …

The focal adhesion kinase (FAK) is a non-receptor tyrosine kinase abundantly expressed in
the mammalian brain and highly enriched in neuronal growth cones. Inhibitory and …

Although it was originally characterized as a constituent of focal adhesions in fibroblasts,
focal adhesion kinase (FAK) is now considered to be not only a mediator of adhesion …

Focal adhesion kinase (FAK) is a protein tyrosine kinase implicated in signal transduction
pathways for integrins, neuropeptides, and lysophosphatidic acid. FAK, first discovered in …

Alzheimer's disease (AD) is a neurodegenerative disorder that results from a loss of synaptic
transmission and ultimately cell death. The presenting pathology of AD includes neuritic …

Focal adhesion kinase (FAK), a nonreceptor protein tyrosine kinase, is frequently
overexpressed in various tumors and its expression shows good correlation with the …

αν and β1 integrins mediate Aβ–induced neurotoxicity in primary hippocampal neurons. We
treated hippocampal neurons with 2.5 µg/mL 17E6 and 5 µg/mL ab58524, which are specific …

Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, is the most
common form of dementia in the elderly. Two major pathological hallmarks have been …