The fungal cell wall serves as the interface between the cell and the environment. Fungal
cell walls are composed largely of polysaccharides, primarily glucans and chitin, though in …

The ability to produce melanin is a key virulence factor in many fungal pathogens including
the human basidiomycete pathogen Cryptococcus neoformans, a major cause of life …

Melanin is an important virulence factor for several microorganisms, including Cryptococcus
neoformans sensu lato and Cryptococcus gattii sensu lato, thus, the assessment of melanin …

Melanins serve a variety of protective functions in plants and animals, but in fungi such as
Cryptococcus neoformans they are also associated with virulence. A recently developed …

Melanin synthesis is associated with virulence for the pathogenic fungus Cryptococcus
neoformans. Exposure of nonmelanized C. neoformans 4067 cells to 4 M guanidinium …

Fungal glucosylceramide (GlcCer) is a plasma membrane sphingolipid in which the
sphingosine backbone is unsaturated in carbon position 8 (C8) and methylated in carbon …

The sphingolipid biosynthetic pathway generates bioactive molecules crucial to the
regulation of mammalian and fungal physiological and pathobiological processes. In …

Prenyltransferase enzymes promote the membrane localization of their target proteins by
directing the attachment of a hydrophobic lipid group at a conserved C-terminal CAAX motif …

Natural brown–black eumelanin pigments confer structural coloration in animals and
potently block ionizing radiation and antifungal drugs. These functions also make them …

Pigment production by Cryptococcus neoformans is virulence associated. Dopamine-and 3,
4-dihydroxyphenylalanine–melanin products were identified after acidic permanganate …