[HTML][HTML] Treatment of myocardial ischaemia-reperfusion injury in patients with ST-segment elevation myocardial infarction: promise, disappointment, and hope

J He, NG Bellenger, AJ Ludman, AC Shore… - Reviews in …, 2022 - imrpress.com
Acute myocardial infarction (AMI) is a major cause of morbidity and mortality worldwide.
Timely reperfusion with primary percutaneous coronary intervention (PPCI) remains the gold …

Low-dose interleukin 2 for the reduction of vascular inflammation in acute coronary syndromes (IVORY): protocol and study rationale for a randomised, double-blind …

R Sriranjan, TX Zhao, J Tarkin, A Hubsch, J Helmy… - BMJ open, 2022 - bmjopen.bmj.com
Introduction Inflammation plays a critical role in the pathogenesis of atherosclerosis, the
leading cause of ischaemic heart disease (IHD). Studies in preclinical models have …

The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study

AC Morton, AMK Rothman, JP Greenwood… - European heart …, 2015 - academic.oup.com
Abstract Aims Acute coronary syndromes (ACSs) are driven by inflammation within coronary
plaque. Interleukin-1 (IL-1) has an established role in atherogenesis and the vessel …

Association of interleukin-10 level with increased 30-day mortality in patients with ST-segment elevation acute myocardial infarction undergoing primary coronary …

HK Yip, AA Youssef, LT Chang, CH Yang… - Circulation …, 2007 - jstage.jst.go.jp
Background The prognostic value of interleukin (IL)-10 in patients with ST-segment
elevation acute myocardial infarction (ST-se AMI) is currently unclear. The purpose of this …

Ischemia–reperfusion injury is still a big hurdle to overcome for treatment of acute myocardial infarction

T Inoue - Journal of Cardiology, 2016 - journal-of-cardiology.com
Since it has been elucidated that myocardial reperfusion can reduce myocardial infarct size
following an acute coronary artery occlusion, nowadays, myocardial reperfusion therapy …

Improving myocardial injury, infarct size, and myocardial salvage in the era of primary PCI for STEMI

G Ndrepepa - Coronary Artery Disease, 2015 - journals.lww.com
ST-segment elevation myocardial infarction (STEMI) is a major cause of mortality and
disability worldwide. Reperfusion therapy by thrombolysis or primary percutaneous coronary …

[PDF][PDF] Association between acute inflammatory response and infarct size in STEMI patients undergoing primary PCI

M Morariu, E Márton, A Mester, M Rațiu… - Journal of …, 2018 - sciendo.com
Background: The inflammatory response of the immune system plays a major role in the
period following an acute myocardial infarction (MI), as it coordinates the formation of the …

[HTML][HTML] Translational overview of cytokine inhibition in acute myocardial infarction and chronic heart failure

MHT Hartman, HE Groot, IM Leach, JC Karper… - Trends in cardiovascular …, 2018 - Elsevier
Many cytokines are currently under investigation as potential target to improve cardiac
function and outcome in the setting of acute myocardial infarction (MI) or chronic heart failure …

[HTML][HTML] Cardioprotection and pharmacological therapies in acute myocardial infarction: Challenges in the current era

A Dominguez-Rodriguez… - World journal of …, 2014 - ncbi.nlm.nih.gov
In patients with an acute ST-segment elevation myocardial infarction, timely myocardial
reperfusion using primary percutaneous coronary intervention is the most effective therapy …

Increased interleukin‐1β levels are associated with left ventricular hypertrophy and remodelling following acute st segment elevation myocardial infarction treated by …

S Ørn, T Ueland, C Manhenke… - Journal of internal …, 2012 - Wiley Online Library
Ørn S, Ueland T, Manhenke C, Sandanger Ø, Godang K, Yndestad A, Mollnes TE, Dickstein
K, Aukrust P (Stavanger University Hospital, Stavanger; Oslo University Hospital …