Chronic diabetic conditions have been associated with certain cerebral complications, that
include neurobehavioral dysfunctional patterns and morphological alterations of neurons …

Background DNA methylation changes have known to downregulate several regulatory
proteins epigenetically during various neurodegenerative disorders. Our study aims to …

Emerging evidence suggests that epigenetic mechanisms regulate aberrant gene
transcription in stress-associated mental disorders. However, it remains to be elucidated …

Epigenetic mechanisms related to diabetes-afflicted CNS complications are largely
unknown. The present study investigated the role of histone acetylation mechanisms …

Accumulating evidence indicates that hyper-glycaemia is deleterious to brain function, in
particular to the hippocampus. It is thought this hippocampal dysfunction may contribute to …

The current study investigates DNA methylation as a possible epigenetic regulator of
transcription associated with aging and cognitive function. Young and aged male Fischer …

Aberrant DNA methylation is involved in many neurodegenerative diseases, such as
Alzheimer's disease (AD), and at the same time, the hippocampus is one of the most …

DNA methylation is a key epigenetic modification of DNA that is catalyzed by DNA
methyltransferases (Dnmt). Increasing evidences suggest that DNA methylation in neurons …

The prevalence and severity of hypertension-induced cognitive impairment increase with the
prolonging of hypertension. The mechanisms of cognitive impairment induced by …

Aim: To study RNA N6-methyladenosine (m6A) modification in the diabetic hippocampus.
Methods: Behavioral tests and staining were performed to evaluate the damage to the …