The present study investigated the effects of exercise on the cardiac nuclear factor (erythroid-
derived 2) factor 2 (NRF2)/Kelch-like ECH-associated protein 1 (KEAP1) pathway in an …

Regular exercise has widespread health benefits. Fundamental to these beneficial effects is
the ability of the heart to intermittently and substantially increase its performance without …

Although exercise derived activation of Nrf2 signaling augments myocardial antioxidant
signaling, the molecular mechanisms underlying the benefits of moderate exercise training …

Key points• For reasons not completely understood, obesogenic high‐fat, high‐sucrose
(HFHS) diets and exercise training both increase free fatty acid utilization and chronic …

Nuclear factor erythroid 2 related factor 2 (Nrf2) signaling maintains the redox homeostasis
and its activation is shown to suppress cardiac maladaptation. Earlier we reported that acute …

Background One of the earliest manifestations of obesity related CVD is diastolic dysfunction
leading to heart failure with preserved ejection fraction (HFpEF). A limitation in developing …

Reactive oxygen and nitrogen species regulate a wide array of signaling pathways that
governs cardiovascular physiology. However, oxidant stress resulting from disrupted redox …

Increase in fructose consumption together with decrease in physical activity contributes to
the development of metabolic syndrome and consequently cardiovascular diseases. The …

Background and Aim: Excessive fructose consumption along with a sedentary lifestyle
provokes metabolic disorders and cardiovascular diseases. Fructose overload causes …

Aging promotes accumulation of reactive oxygen/nitrogen species (ROS/RNS) in
cardiomyocytes, which leads to contractile dysfunction and cardiac abnormalities. These …