Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints
that inhibits the activation of immune cells through the interaction with its ligand CD24 on …

Simple Summary Sialylation is the synthetic process of sialoglycans, which are important in
tumor transformation, proliferation, metastasis, and immune evasion. The primary subjects of …

Cancer cells can develop various mechanisms to evade tumorspecific and non-specific
attacks in the TME of solid tumors. 2 Thus, systemic activation of immune systems or even …

The Siglec family of cell surface receptors have emerged as attractive targets for cell-
directed therapies due to their restricted expression on immune cells, endocytic properties …

The immune system must be tightly held in check to avoid bystander tissue damage as well
as autoreactivity caused by overwhelming immune reactions. A novel family of …

Sialylated glycan structures are known for their immunomodulatory capacities and their
contribution to tumor immune evasion. However, the role of aberrant sialylation in colorectal …

Aberrant sialylation functions as an important modulator of all steps of malignant
transformation. Therefore, targeting sialylation regulators, such as sialyltransferases and …

Autoimmune diseases (ADs) are currently treated with anti‐inflammatory and
immunosuppressive drugs, aimed at reducing symptoms of disease in order to improve …

Siglecs (Sialic acid-binding immunoglobulin-type lectins) are a I-type lectin that typically
binds sialic acid. Siglecs are predominantly expressed in immune cells and generate …

We previously demonstrated that Siglec-15, a member of the Siglec family of glycan-
recognition proteins, is expressed on a subset of macrophages and preferentially …