Sirolimus is an immunosupressive drug that specifically inhibit the activation of T-
lymphocytes. This study was undertaken to investigate whether treatment with sirolimus …

Recent studies have revealed that T lymphocytes play a role in neuropathic pain following
nerve injury in rats through releasing several cytokines. Sirolimus is an immunosuppressive …

Objective and Design: To determine whole blood levels of sirolimus, a macrolide antibiotic in
the rat developing adjuvant arthritis (AA) model after dosing orally with two different vehicles …

Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting the synovial
membrane of joints. In this study, we aimed to investigate whether sorafenib exerts …

FK506 and cyclosporin A (CsA) are immunosuppressive drugs, that specifically inhibit T‐cell
activation via calcineurin inhibition. This study was undertaken to investigate whether …

Effects and mechanisms of FR167653, 1-[7-(4-fluorophenyl)-1, 2, 3, 4-tetrahydro-8-(4-
pyridyl) pyrazolo [5, 1-c][1, 2, 4] triazin-2-yl]-2-phenylethanedione sulfate monohydrate, a …

Anti-tumor necrosis factor-α (TNFα) antibody in combination with methotrexate dramatically
decreases joint destruction in rheumatoid arthritis. The aim of this study was to examine …

Epidermal growth factor receptor (EGFR) and its ligands are commonly expressed by
synovial cells. The aim of the present study was to detect the potential effect of lapatinib an …

Although the precise etiology of Rheumatoid arthritis (RA) remains obscure, heightened
immune response is thought to play a vital role in provoking joint inflammation and bone …

The aim of this study, evaluate the nociceptive effect of adalimumab, a TNF-alpha inhibitor,
on formalin-induced inflammatory pain in mice. The antinociceptive activity of adalimumab …