Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …

Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain, including neuropathic pain. While this comorbidity is clinically …

For many patients, chronic pain is often accompanied, and sometimes amplified, by co-
morbidities such as anxiety and depression. Although it represents important challenges, the …

Affective disorders and cognitive deficits are common comorbidities of chronic pain in the
clinical setting, which severely affect the quality of life of pain patients and impose a great …

The use of genetically manipulated animals in conjunction with classical physiological and
biochemical measurement has unravelled many pathological changes in animal models of …

The measurement of spontaneous ongoing pain in rodents is a multiplex issue and a subject
of extensive and longstanding debate. Considering the need to align available rodent …

BACKGROUND: Chronic pain is clinically associated with the development of affective
disorders. However, studies in animal models of neuropathic pain are contradictory and the …

Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

Pain is ultimately a perceptual phenomenon. It is built from information gathered by
specialized pain receptors in tissue, modified by spinal and supraspinal mechanisms, and …

In recent years, the disappointing history of translation in pain research has undergone
significant scrutiny. The escalation of knowledge and understanding related to presumed …