Lost in translation: Neurotrophins biology and function in the neurovascular unit

G Mirzahosseini, JM Adam, S Nasoohi… - The …, 2023 - journals.sagepub.com
The neurovascular unit (NVU) refers to the functional building unit of the brain and the retina,
where neurons, glia, and microvasculature orchestrate to meet the demand of the retina's …

Implication of the neurotrophin receptor p75NTR in vascular diseases: beyond the eye

SL Elshaer, AB El-Remessy - Expert review of ophthalmology, 2017 - Taylor & Francis
Introduction: The p75 neurotrophin receptor (p75NTR) is a member of TNF-α receptor
superfamily that bind all neurotrophins, mainly regulating their pro-apoptotic actions …

Pathophysiological mechanisms for actions of the neurotrophins

JL Twiss, JH Chang, NC Schanen - Brain Pathology, 2006 - Wiley Online Library
Neurotrophins provide trophic and tropic support for different neuronal subpopulations in the
developing and adult nervous systems. Expression of the neurotrophins and their receptors …

Neurotrophins and their receptors: roles in plasticity, neurodegeneration and neuroprotection

A Hennigan, RM O'callaghan, AM Kelly - 2007 - portlandpress.com
It is beyond doubt that the neurotrophin family of proteins plays key roles in determining the
fate of the neuron, not only during embryonic development, but also in the adult brain …

The yin and yang of neurotrophin action

B Lu, PT Pang, NH Woo - Nature Reviews Neuroscience, 2005 - nature.com
Neurotrophins have diverse functions in the CNS. Initially synthesized as precursors
(proneurotrophins), they are cleaved to produce mature proteins, which promote neuronal …

Neurotrophins and neurotrophin receptors

ML Franco, R Comaposada-Baró, M Vilar - Hormonal Signaling in Biology …, 2020 - Elsevier
Neurotrophins are a family of secreted proteins that promote different activities during
development and in the adult nervous system, like cell survival and differentiation, synaptic …

The role of neurotrophins in axonal growth, guidance, and regeneration

MG Lykissas, AK Batistatou… - Current …, 2007 - ingentaconnect.com
Neurotrophins are proteins that regulate neuronal survival, axonal growth, synaptic plasticity
and neurotransmission. They are members of the neurotrophic factors family and include …

Neurotrophins: roles in neuronal development and function

EJ Huang, LF Reichardt - Annual review of neuroscience, 2001 - annualreviews.org
▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …

The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors

SD Skaper - CNS & Neurological Disorders-Drug Targets …, 2008 - ingentaconnect.com
The neurotrophins are a family of closely related proteins that were first identified as survival
factors for sympathetic and sensory neurons, and have since been shown to control a …

Neurotrophin signaling and stem cells—implications for neurodegenerative diseases and stem cell therapy

S Pramanik, YA Sulistio, K Heese - Molecular neurobiology, 2017 - Springer
Neurotrophins (NTs) are members of a neuronal growth factor protein family whose action is
mediated by the tropomyosin receptor kinase (TRK) receptor family receptors and the p75 …