After ovulation, metaphase II oocytes undergo a time-dependent deterioration in vivo or in
vitro, which is referred to as postovulatory oocyte aging, a process during which a series of …

The NAD+‐dependent sirtuin deacetylase, Sirt1, regulates key transcription factors strongly
implicated in ageing and lifespan. Due to potential confounding effects secondary to loss of …

Mammalian oocytes remain arrested at the first prophase of meiosis in ovarian follicles for
an extended period. During this protracted arrest, oocytes are remarkably susceptible to the …

Increasing evidence shows that melatonin protected against age-related mitochondrial
oxidative damage. However, the protective effects of melatonin against ovarian aging has …

Loss of follicles together with decreased oocyte quality and quantity contribute to age-
associated ovarian senescence and infertility. Although underlying mechanisms for ovarian …

Aging has a major detrimental effect on the optimal function of the ovary with changes in this
organ preceding the age-related deterioration in other tissues, with the middle-aged …

Abstract STUDY QUESTION Is SIRT1 involved in the oxidative stress (OS) response in
mouse oocytes? SUMMARY ANSWER SIRT1 plays a pivotal role in the adaptive response …

It has been well recognized that oocyte quality declines in aging animals. However, to date,
the underlying mechanism remains to be explored. In the present study, we report that …

Oxidative stress is known as a major contributing factor involved in oocyte aging, which
negatively affects oocyte quality and development after fertilization. Melatonin is an effective …

Abstract Sirtuin-3 (SIRT3), the main deacetylase in the mitochondria, maintains cellular
energy metabolism and redox balance by deacetylating mitochondrial proteins in a NAD+ …