In previous studies, oxidative stress damage has been solely considered to be the
mechanism of ovarian aging, and several antioxidants have been used to delay ovarian …

While at the organismal level, biological aging can be estimated by telomere length and
DNA methylation signatures, reliable biomarkers that can predict reproductive age are much …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is capable of inducing a variety of biological
effects, and the regulation of the Nrf2 signaling pathway is closely related to longevity. To …

Recent advances highlight the pivotal role of nicotinamide adenine dinucleotide (NAD+) in
ovarian aging. However, the roles of de novo NAD+ biosynthesis on ovarian aging are still …

Background The global delay in women's reproductive age has raised concerns about age-
related infertility. The decline in oocyte quality is a limiting factor of female fertility, yet there …

Maternal aging adversely affects oocyte quality (function and developmental potential) and
consequently lowers pregnancy rates while increasing spontaneous abortions. Substantial …

In search for strategies aimed at preventing oxidative threat to female fertility, a possible role
of sirtuins has emerged. Sirtuins (silent information regulator 2 (Sir2) proteins), NAD+ …

Reproductive aging in female mammals is an irreversible process associated with declining
oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of …

It is well established that age-related decline of a woman's fertility is related to the poor
developmental potential of her gametes. The age-associated decline in female fertility is …

The level of Sirt2 protein is reduced in oocytes from aged mice, while exogenous expression
of Sirt2 could ameliorate the maternal age‐associated meiotic defects. To date, the …