Reactive oxygen species (ROS) are essential for sperm physiological functions such as
capacitation, hyperactivation, and acrosome reaction, on the one hand, and for stimulating …

Increases in delayed childbearing worldwide have elicited the need for a better
understanding of the biological underpinnings and implications of age-related infertility. In …

Objective Oxidative stress is a postulated etiology of spontaneous preterm birth (PTB) and
preterm prelabor rupture of the membranes (pPROM); however, the precise mechanistic role …

Cellular senescence is a phenomenon occurring when cells are no longer able to divide
even after treatment with growth stimuli. Because senescent cells are typically associated …

Background Oocytes may undergo two types of aging. The first is induced by exposure to an
aged ovarian microenvironment before being ovulated, known as 'reproductive or maternal …

Abstract Melatonin (N-acetyl-5-methoxytryptamine) is secreted during the dark hours at night
by pineal gland, and it regulates a variety of important central and peripheral actions related …

Women with reduced ovarian reserve or advanced maternal age have an altered metabolic
follicular microenvironment. As sirtuin 5 (SIRT5) senses cellular metabolic state and post …

SIRT 4 modulates energy homeostasis in multiple cell types and tissues. However, its role in
meiotic oocytes remains unknown. Here, we report that mouse oocytes overexpressing SIRT …

BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and
quality as well as uterine and placental dysfunctions. These changes lead to infertility …

Melatonin is probably produced in all cells but is only secreted by the pineal gland. The
pineal secretion of melatonin is determined by the light–dark cycle, and it is only released at …