Transcriptional Profiling of Pseudomonas aeruginosa Infections

JG Thöming, S Häussler - Pseudomonas aeruginosa: Biology …, 2022 - Springer
Pseudomonas aeruginosa is an opportunistic pathogen that causes life-devastating acute
as well as chronic biofilm-associated infections with limited treatment options. Its success is …

In-Vivo Expression Profiling of Pseudomonas aeruginosa Infections Reveals Niche-Specific and Strain-Independent Transcriptional Programs

P Bielecki, J Puchałka, ML Wos-Oxley, H Loessner… - PloS one, 2011 - journals.plos.org
Pseudomonas aeruginosa is a threatening, opportunistic pathogen causing disease in
immunocompromised individuals. The hallmark of P. aeruginosa virulence is its multi …

A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence

D Balasubramanian, L Schneper, H Kumari… - Nucleic acids …, 2013 - academic.oup.com
Pseudomonas aeruginosa is a metabolically versatile bacterium that is found in a wide
range of biotic and abiotic habitats. It is a major human opportunistic pathogen causing …

Convergent Within-Host Adaptation of Pseudomonas aeruginosa through the Transcriptional Regulatory Network

YE Gatt, D Savion, T Bamberger, H Margalit - Msystems, 2023 - Am Soc Microbiol
Bacteria adapt to their host by mutating specific genes and by reprogramming their gene
expression. Different strains of a bacterial species often mutate the same genes during …

The Single-Nucleotide Resolution Transcriptome of Pseudomonas aeruginosa Grown in Body Temperature

O Wurtzel, DR Yoder-Himes, K Han, AA Dandekar… - 2012 - journals.plos.org
One of the hallmarks of opportunistic pathogens is their ability to adjust and respond to a
wide range of environmental and host-associated conditions. The human pathogen …

Bacterial adaptation during chronic infection revealed by independent component analysis of transcriptomic data

L Yang, MH Rau, L Yang, N Høiby, S Molin, L Jelsbak - BMC microbiology, 2011 - Springer
Background Bacteria employ a variety of adaptation strategies during the course of chronic
infections. Understanding bacterial adaptation can facilitate the identification of novel drug …

The Pseudomonas aeruginosa transcriptional landscape is shaped by environmental heterogeneity and genetic variation

A Dötsch, M Schniederjans, A Khaledi, K Hornischer… - MBio, 2015 - Am Soc Microbiol
Phenotypic variability among bacteria depends on gene expression in response to different
environments, and it also reflects differences in genomic structure. In this study, we analyzed …

Compendium-wide analysis of P. aeruginosa core and accessory genes reveal more nuanced transcriptional patterns

AJ Lee, G Doing, SL Neff, T Reiter, DA Hogan… - bioRxiv, 2022 - biorxiv.org
Strains of Pseudomonas aeruginosa, an opportunistic pathogen that causes difficult to treat
infections, have significant genomic heterogeneity including the presence of diverse …

Ex vivo transcriptional profiling reveals a common set of genes important for the adaptation of Pseudomonas aeruginosa to chronically infected host sites

P Bielecki, U Komor, A Bielecka… - Environmental …, 2013 - Wiley Online Library
The opportunistic bacterium P seudomonas aeruginosa is a major nosocomial pathogen
causing both devastating acute and chronic persistent infections. During the course of an …

An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence

T Wang, W Sun, L Fan, C Hua, N Wu, S Fan, J Zhang… - Elife, 2021 - elifesciences.org
A high-throughput systematic evolution of ligands by exponential enrichment assay was
applied to 371 putative TFs in Pseudomonas aeruginosa, which resulted in the robust …