Capsaicin and other naturally occurring pungent molecules have been used for centuries as
topical analgesics to treat a variety of painful conditions. However, only within the last 12 …

The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known
for its sensitivity to pungent vanilloid compound (ie capsaicin) and noxious stimuli, including …

In peripheral sensory neurons, the vanilloid receptor TRPV1 (transient receptor potential
vanilloid subfamily, member 1) functions as a molecular integrator of painful stimuli …

The TRPV1 vanilloid receptor, first cloned and characterized in 1997, is a non-selective
cation channel expressed in primary sensory neurons, and is a key pain sensor and …

Examines the emerging therapeutic role of TRPV1 TRPV1 is considered an integrator of
noxious stimuli and therefore may be at a crossroads for pain transmission pathways …

Background: The capsaicin receptor TRPV1, a polymodal nociceptor whose expression is
up-regulated in a number of painful inflammatory disorders, represents a promising …

The vanilloid receptor TRPV1 is a homotetrameric, non-selective cation channel abundantly
expressed in the nociceptors (c-fibers). TRPV1 is considered as a highly validated pain …

BACKGROUND Nociceptors are primary sensory afferent (Cand Aö fibers) neurons that are
activated by a wide variety of noxious stimuli including chemical, mechanical, thermal, and …

Inflammatory pain is a condition caused by tissue injury and requires efficient drug
treatment. The identification and cloning of the vanilloid receptor TRPV1 represents a …

Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel,
predominantly expressed in a subset of peripheral sensory neurons for pain signaling …