Nuclear localization of the pyruvate kinase M2 isoform (PKM2) is widely observed in cancer
and correlates with its aggressiveness, but its contribution to gene regulation and …

Nuclear localization of the pyruvate kinase M2 isoform (PKM2) is widely observed in cancer
and correlates with its aggressiveness, but its contribution to gene regulation and …

Nuclear localization of the metabolic enzyme PKM2 is widely observed in various cancer
types. We identify nuclear PKM2 as a non-canonical RNA-binding protein (RBP) that …

Pyruvate kinase is a rate-limiting glycolytic enzyme. The PKM1 and PKM2 isoforms result
from mutually exclusive alternative splicing of the PKM pre-mRNA. PKM2 rather than PKM1 …

Background RNA secondary structures in the 5′-untranslated regions (5′-UTR) of mRNAs
are key to the post-transcriptional regulation of gene expression. While it is evident that non …

Alternative splicing of the pyruvate kinase M (PKM) pre-mRNA generates two isoforms,
PKM1 and PKM2. PKM catalyzes the conversion of phosphoenol-pyruvate to pyruvate in …

Guanine-rich RNA sequences can fold into four-stranded structures, termed G-quadruplexes
(G4-RNAs), whose biological roles are poorly understood, and in vivo existence is debated …

Understanding of the microRNAs (miRNAs) regulatory system has become indispensable
for physiological/oncological research. Tissue and organ specificities are key features of …

It has been demonstrated that RNA G-quadruplexes (G4) are structural motifs present in
transcriptomes and play important regulatory roles in several post-transcriptional …

Abstract Guanine-quadruplexes (G4s) are non-canonical four-stranded structures that can
be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences …