Cocaine is a commonly abused central nervous system stimulant that enhances dopamine
(DA) neurotransmission through its ability to block dopamine transporters (DAT s). Recent …

Cocaine produces its reinforcing effects primarily by inhibiting the dopamine transporter
(DAT) at the level of presynaptic terminals and increasing extracellular levels of dopamine …

BACKGROUND:: Psychomotor stimulant drugs such as cocaine and amphetamine activate
brain dopamine (DA) neurotransmission and support self-administration in humans and …

An involvement of the D3 dopamine receptor in the regulation of extracellular dopamine has
been suggested. However, the mechanisms mediating this effect are unclear. We have used …

Dopamine receptor subtypes have been classified generally as D1-like (eg, D1, D5) or D2-
like (D2, D3, D4), and converging evidence suggests that D2-like receptors may be …

Cocaine is a psychostimulant and a drug widely abused by humans. Cocaine elicits its
effects primarily by blocking the activity of the dopamine (DA) transporter, leading to …

A major theme of addiction research has focused on the neural substrates of individual
differences in the risk for addiction; however, little is known about how vulnerable …

Dopamine (DA) D2 receptors expressed in DA neurons (D2 autoreceptors) exert a negative
feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D2 …

J. Neurochem.(2011) 118, 714–720. Abstract Dopamine (DA) is an important transmitter in
both motor and limbic pathways. We sought to investigate the role of D1‐receptor activation …

Pharmacological studies have shown that blockade of the dopamine D1 receptor attenuates
locomotor behaviors and prevents sensitization to psychostimulants. However, due to …