In 1988, Yanagisawa et al. reported the presence of a potent peptide from the supernatant of
porcine endothelial cells. This was later named endothelin‐1 (ET‐1) and was found to …

The endothelium synthesizes and releases paracrine hormones that regulate the contraction
and physiology of vascular smooth muscle cells. 1-3 In addition to the well-described …

Since the discovery of the most potent vasoconstrictor peptide, endothelin, in 1988,
explosive investigations have rapidly clarified much of the basic pharmacological …

The physiologic significance of endothelin-1 (ET-1) generation in human resistance vessels
is unknown. We therefore investigated whether endothelin-converting enzyme (ECE) activity …

1. Brachial artery infusion of endothelin (ET)‐1 causes transient vasodilatation followed by
sustained vasoconstriction of the forearm vascular bed, whereas ET‐1 antagonists cause …

Endothelin-1 (ET-1) is a potent vasoconstrictive peptide produced by endothelial cells of
blood vessels. This peptide has quite a unique structure and pharmacological properties. ET …

Endothelin‐1 modulates vascular smooth muscle tone by exerting potent vasoconstrictor
actions through the ETA receptor subtype located on the membranes of vascular smooth …

In vascular beds, a potent vasoconstrictor of endothelin-1 (ET-1) is produced by endothelial
cells and released preferentially to the basal side of endothelial cells. It acts on endothelial …

Endothelin (ET) is a potent vasoconstrictive peptide initially found in the conditioned medium
of cultured endothelial cells (1). It comprises 21 amino acid residues including four cysteine …

In an anesthetized rat, endothelin-1 (ET-1) causes a rapid, transient fall in blood pressure
followed by a large, sustained rise. Rat endothelin-3 (ET-3) differs from porcine endothelin-1 …