Impaired insulin sensitivity, also termed insulin resistance, is generally defined as reduced
glucose clearance in skeletal muscle, impaired suppression of glucose production by the …

This chapter contains sections titled: Insulin resistance–definitions and role in the natural
history of type 2 diabetes Metabolic syndrome and non‐alcoholic fatty liver disease Insulin …

About 70 years ago, Himsworth and Kerr published evidence based on the results from
modified oral glucose tolerance tests that the ability of insulin to stimulate glucose uptake …

Insulin resistance in peripheral tissues and in the brain are fundamental to the development
of obesity and its associated type 2 diabetes. Multiple mechanisms contribute to the …

Insulin resistance is the pivotal pathogenic component of many metabolic diseases,
including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of …

The ability of insulin to stimulate muscle glucose disposal and inhibit adipose tissue lipolysis
is impaired in patients with type 2 diabetes. The progression from normal glucose tolerance …

Insulin resistance, defined as a reduced biological action of insulin, has emerged as a major
factor in the development and progression of a number of common non-communicable …

Mechanisms of insulin resistance in subjects at risk for type 2 diabetes remain to be
elucidated. Insulin acts slowly in vivo, but rapidly in vitro, suggesting that the pathway insulin …

For long the presence of insulin resistance in type 1 diabetes has been questioned. Detailed
metabolic analyses revealed 12%–61% and up to 20% lower whole-body (skeletal muscle) …

Following the discovery of insulin by Banting and Best in 1922, it was widely assumed that
human diabetes was due exclusively to a deficiency in the secretion of the hormone …