Classically, the metabolic syndrome is characterized as group of pathologies including
visceral obesity, hypertension, dyslipidemia, and impaired glucose tolerance. It is now …

These data point to a central role for insulin resistance in the pathogenesis of the metabolic
syndrome, as hyperglycemia, atherosclerosis, and cholesterol gallstones can all be caused …

Summary. Type 2 diabetes is a heterogeneous condition that is not attributable to a single
pathophysiological mechanism. In general, both insulin resistance and impaired insulin …

INTRODUCTION I t has been known that insulin resistance and hyper-insulinemia are the
hallmark features of non-insulin-dependent diabetes mellitus (NIDDM) and obesity.'r2 In …

Insulin resistance was already suspected in the thirties from clinical observations in diabetic
patients, then better appreciated in the early sixties with the development of insulin …

In the transition from normal glucose tolerance (NGT) to type 2 diabetes mellitus (T2DM), the
role of β-cell dysfunction and peripheral insulin resistance (IR) is well established. However …

Insulin resistance is a prominent feature of three clinical conditions: obesity, impaired
glucose tolerance, and non-insulin-dependent (type II) diabetes mellitus. Numerous studies …

Etiopathogenesis of type 2 diabetes is complex and still partially unknown. Its etiology is
determined by the interaction of genetic and environmental factors. The genetic contribution …

Insulin resistance is a hallmark of type 2 diabetes mellitus and is associated with a metabolic
and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially …

Insulin resistance arises when the nutrient storage pathways evolved to maximize efficient
energy utilization are exposed to chronic energy surplus. Ectopic lipid accumulation in liver …