Although Nef is the viral gene product used by most simian immunodeficiency viruses to
overcome restriction by tetherin, this activity was acquired by the Vpu protein of HIV-1 group …

Simian immunodeficiency viruses (SIVs) use their Nef proteins to counteract the restriction
factor tetherin. However, a deletion in human tetherin prevents antagonism by the Nef …

Most simian immunodeficiency viruses use their Nef protein to antagonize the host
restriction factor tetherin. A deletion in human tetherin confers Nef resistance, representing a …

The host restriction factor tetherin inhibits virion release from infected cells and poses a
significant barrier to successful zoonotic transmission of primate lentiviruses to humans …

In different primate lentiviruses, three proteins (Vpu, Env and Nef) have been shown to have
anti-tetherin activities. SIVden is a primate lentivirus harbored by a Cercopithecus denti (C …

Summary The tetherin/BST2/CD317 protein blocks the release of HIV-1 and other
enveloped viruses by inducing tethering of nascent particles to infected cell surfaces. The …

Bone Marrow Stromal Cell Antigen 2 (BST-2)/tetherin inhibits the release of numerous
enveloped viruses by physically tethering nascent particles to infected cells during the …

Background HIV-1 viruses are categorized into four distinct groups: M, N, O and P. Despite
the same genomic organization, only the group M viruses are responsible for the world-wide …

The interferon-induced host restriction factor tetherin poses a barrier for SIV transmission
from primates to humans. After cross-species transmission, the chimpanzee precursor of …

The multifunctional Nef protein of primate lentiviruses is commonly considered an early viral
factor that downmodulates various receptors from the cell surface and modulates several …