Since the end of the 1980s, key discoveries have been made which have significantly
revived the scientific interest in a cell organelle, which has been studied continuously and …

Mitochondria, the powerhouse of the cell, have been known for many years for their central
role in the energy metabolism; however, extensive progress has been made and to date …

This review attempts to summarize our present state of knowledge of mitochondria in
relation to a number of areas of biology, and to indicate where future research might be …

Mitochondria are being recognized as key factors in many unexpected areas of biomedical
science. In addition to their well-known roles in oxidative phosphorylation and metabolism, it …

Mitochondria play a central role in energy metabolism within the cell. Mitochondrial
dysfunctions lead to various neurodegenerative disorders and to the so-called …

Mitochondrial dysfunction has been associated with the aging process and a large variety of
human disorders, such as cardiovascular and neurodegenerative diseases, cancer …

Background: Targeting of drugs to the subcellular compartments represents one of the
modern trends in molecular pharmacology. The approach for targeting mitochondria was …

Significance: Mitochondria exert vital functions during normal physiology and are also
centrally involved in the regulation of various modes of cell death. Thus, engaging the …

The chapters throughout this volume illustrate the many contributions of mitochondria to the
maintenance of normal cell and tissue function, experienced as the health of the individual …

Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …