The cluster of differentiation 40 (CD40) is activated by the CD40 ligand (CD40L) in a variety
of diverse cells types and regulates important processes associated with kidney disease …

Abstract Soluble CD40 ligand (sCD40L) has been implicated in the development of renal
injury. The CD40 receptor exists in a soluble form, sCD40R, and has been shown to function …

CD40 and its ligand (CD40L) regulate several cellular functions, including T and B-cell
activation. The soluble form of CD40 (sCD40) antagonizes CD40/CD40L interaction …

Lupus nephritis (LN) is a significant complication of systemic lupus erythematosus (SLE),
increasing its morbidity and mortality. Although the current standard of care helps suppress …

Activation of the CD40 receptor on the proximal tubular epithelium of the kidney results in
fibrosis and inflammation in experimental models of kidney injury. Soluble CD40 ligand is …

Infiltration of immune cells into the renal interstitium is characteristic of chronic inflammatory
kidney diseases. CD4+ T cells and platelets express CD40 ligand (CD40L) and are reported …

Blockade of CD40-CD40 ligand protects against renal injury in chronic proteinuric renal
disease. Background Interaction between CD40 and CD40 ligand (CD40L) is involved in …

Evidence suggests that human and experimental crescentic GN results from Th1-
predominant immunity to glomerular antigens. CD40/CD154 signaling plays a key role in …

CD40/CD40 ligand (CD40L) dyad, a co-stimulatory bi-molecular complex involved in the
adaptive immune response, has also potent pro-inflammatory actions in haematopoietic and …

CD40 is a costimulatory receptor on APCs that is critical for the induction and maintenance
of humoral and cell-mediated immunity. Accordingly, CD40 and its ligand, CD40L, have long …