Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic
acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2. The role of …

It is well admitted that the link between chronic inflammation and cancer involves cytokines
and mediators of inflammatory pathways, which act during the different steps of …

Increased prostaglandin (PG) production is associated with many inflammatory
pathophysiological conditions; it is derived from arachidonic acid by either of two enzymes …

Aspirin has been used to control pain and inflammation for over a century. Epidemiological
studies first associated a decreased incidence of colorectal cancer with the long-term use of …

Cyclooxygenase-2 (Cox-2) is an inducible enzyme involved in the conversion of arachidonic
acid to prostaglandin and other eicosanoids. Molecular pathology studies have revealed …

Abstract Cyclooxygenase‐2 (COX‐2) is the inducible isoform of cyclooxygenase, the
enzyme that catalyzes the rate‐limiting step in prostaglandin synthesis from arachidonic …

The recent marketing of two selective cyclooxygenase-2 (COX-2) inhibitors, celecoxib and
rofecoxib is remarkable considering that COX-2 was only discovered eight years ago as a …

Several types of human tumors overexpress cyclooxygenase (COX)-2 but not COX-1, and
gene knockout transfection experiments demonstrate a central role of COX-2 in …

Cancer is a major cause of death worldwide despite significant advances in surgery and
biology. Several recent studies have suggested that there is a close connection between …

Cyclooxygenase (COX) is an enzyme complex that plays an important role in the conversion
of arachidonic acid to prostaglandins. Prostaglandins are essential modulators of signal …